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Open Access
Peer-reviewed
Research Article
Metabolic Signatures of Adiposity in Young Adults: Mendelian Randomization Analysis and Effects of Weight Change
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Peter Würtz ,
* E-mail: peter.wurtz@computationalmedicine.fi (PW); mika.ala-korpela@computationalmedicine.fi (MAK)
Affiliations Computational Medicine, Institute of Health Sciences, University of Oulu, Oulu, Finland, Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland
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Qin Wang,
Affiliations Computational Medicine, Institute of Health Sciences, University of Oulu, Oulu, Finland, NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland
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Antti J. Kangas,
Affiliations Computational Medicine, Institute of Health Sciences, University of Oulu, Oulu, Finland, NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland
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Rebecca C. Richmond,
Affiliation MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom
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Joni Skarp,
Affiliation Computational Medicine, Institute of Health Sciences, University of Oulu, Oulu, Finland
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Mika Tiainen,
Affiliations Computational Medicine, Institute of Health Sciences, University of Oulu, Oulu, Finland, NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland
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Tuulia Tynkkynen,
Affiliations Computational Medicine, Institute of Health Sciences, University of Oulu, Oulu, Finland, NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland
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Pasi Soininen,
Affiliations Computational Medicine, Institute of Health Sciences, University of Oulu, Oulu, Finland, NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland
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Aki S. Havulinna,
Affiliations Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland
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Marika Kaakinen,
Affiliation Institute of Health Sciences and Biocenter Oulu, University of Oulu, Oulu, Finland
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Jorma S. Viikari,
Affiliation Department of Medicine, University of Turku and Turku University Hospital, Turku, Finland
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Markku J. Savolainen,
Affiliation Department of Internal Medicine, Clinical Research Center and Biocenter Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland
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Mika Kähönen,
Affiliation Department of Clinical Physiology, University of Tampere and Tampere University Hospital, Tampere, Finland
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Terho Lehtimäki,
Affiliation Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere, Tampere, Finland
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Satu Männistö,
Affiliation Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland
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Stefan Blankenberg,
Affiliation University Heart Center Hamburg, Hamburg, Germany
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Tanja Zeller,
Affiliation University Heart Center Hamburg, Hamburg, Germany
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Jaana Laitinen,
Affiliation Finnish Institute of Occupational Health, Helsinki, Finland
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Anneli Pouta,
Affiliations Department of Obstetrics and Gynecology, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland, Department of Children, Young People and Families, National Institute for Health and Welfare, Oulu, Finland
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Pekka Mäntyselkä,
Affiliation Primary Health Care, School of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland
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Mauno Vanhala,
Affiliations Primary Health Care, School of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland, Primary Health Care, Central Finland Central Hospital, Jyväskylä, Finland
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Paul Elliott,
Affiliation Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, Imperial College London, London, United Kingdom
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Kirsi H. Pietiläinen,
Affiliations Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland, Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland, Research Programs Unit Diabetes and Obesity, University of Helsinki, Helsinki, Finland
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Samuli Ripatti,
Affiliations Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland, Wellcome Trust Sanger Institute, Hinxton, United Kingdom, Hjelt Institute, Department of Public Health, University of Helsinki, Helsinki, Finland
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Veikko Salomaa,
Affiliation Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland
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Olli T. Raitakari,
Affiliations Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland, Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland
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Marjo-Riitta Järvelin,
Affiliations Institute of Health Sciences and Biocenter Oulu, University of Oulu, Oulu, Finland, Department of Children, Young People and Families, National Institute for Health and Welfare, Oulu, Finland, Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, Imperial College London, London, United Kingdom, Oulu University Hospital, Oulu, Finland
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George Davey Smith,
Affiliation MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom
⨯ - [ ... ],
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Mika Ala-Korpela
* E-mail: peter.wurtz@computationalmedicine.fi (PW); mika.ala-korpela@computationalmedicine.fi (MAK)
Affiliations Computational Medicine, Institute of Health Sciences, University of Oulu, Oulu, Finland, NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland, MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom, Oulu University Hospital, Oulu, Finland, Computational Medicine, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom
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Metabolic Signatures of Adiposity in Young Adults: Mendelian Randomization Analysis and Effects of Weight Change
- Peter Würtz,
- Qin Wang,
- Antti J. Kangas,
- Rebecca C. Richmond,
- Joni Skarp,
- Mika Tiainen,
- Tuulia Tynkkynen,
- Pasi Soininen,
- Aki S. Havulinna,
- Marika Kaakinen
- Published: December 9, 2014
- https://doi.org/10.1371/journal.pmed.1001765