About the Authors

Brian E. Lacy

Affiliation Dartmouth-Hitchcock Medical Center, Lebanon, NH, United States of America

Ron Schey

Affiliation University of Iowa Hospitals and Clinics, Iowa City, IA, United States of America

Steven J. Shiff

Affiliation Forest Laboratories LLC, a subsidiary of Actavis plc, Jersey City, NJ, United States of America

Bernard J. Lavins

Affiliation Ironwood Pharmaceuticals, Cambridge, MA, United States of America

Susan M. Fox

Affiliation Forest Laboratories LLC, a subsidiary of Actavis plc, Jersey City, NJ, United States of America

Xinwei D. Jia

Affiliation Forest Laboratories LLC, a subsidiary of Actavis plc, Jersey City, NJ, United States of America

Rick E. Blakesley

Affiliation Forest Laboratories LLC, a subsidiary of Actavis plc, Jersey City, NJ, United States of America

Xinming Hao

Affiliation Ironwood Pharmaceuticals, Cambridge, MA, United States of America

Jacquelyn A. Cronin

jcronin@ironwoodpharma.com

Affiliation Ironwood Pharmaceuticals, Cambridge, MA, United States of America

Mark G. Currie

Affiliation Ironwood Pharmaceuticals, Cambridge, MA, United States of America

Caroline B. Kurtz

Affiliation Ironwood Pharmaceuticals, Cambridge, MA, United States of America

Jeffrey M. Johnston

Affiliation Ironwood Pharmaceuticals, Cambridge, MA, United States of America

Anthony J. Lembo

Affiliation Beth Israel Deaconess Medical Center, Boston, MA, United States of America

Competing Interests

The authors have read the journal's policy and have the following competing interests: Drs. Brian E. Lacy (BEL) and Anthony J. Lembo (AJL) have served as paid consultants to Forest Laboratories and Ironwood Pharmaceuticals. Bernard J. Lavins, Xinming Hao, Jacquelyn A. Cronin, Mark G. Currie, Caroline B. Kurtz, and Jeffrey M. Johnston (BJL, XH, JAC, MGC, CBK, and JMJ) are employees of Ironwood Pharmaceuticals and own stock/stock options in Ironwood Pharmaceuticals. Steven J. Shiff, Susan M. Fox, Xinwei D. Jia, and Rick E. Blakesley (SJS, SMF, XDJ, and REB) are employees of Forest Laboratories and also own stock/stock options in Actavis plc. Actavis plc acquired Forest Laboratories, LLC in July 2014. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: SJS BJL SMF XDJ MGC CBK JMJ. Performed the experiments: RS. Analyzed the data: XDJ REB XH. Wrote the paper: BEL AJL JMJ JAC. Interpretation of data: BEL SJS BJL XDJ REB XH JAC JMJ AJL. Critical revision of the manuscript for important intellectual content: BEL RS SJS BJL SMF XDJ REB XH JAC MGC CBK JMJ AJL. Study supervision: SJS SMF.