Mitotic Slippage and Expression of Survivin Are Linked to Differential Sensitivity of Human Cancer Cell-Lines to the Kinesin-5 Inhibitor Monastrol

Hila Asraf; Rachel Avunie-Masala; Michal Hershfinkel; Larisa Gheber

doi:10.1371/journal.pone.0129255

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Open Access

Peer-reviewed

Research Article

Mitotic Slippage and Expression of Survivin Are Linked to Differential Sensitivity of Human Cancer Cell-Lines to the Kinesin-5 Inhibitor Monastrol

Hila Asraf ,

Contributed equally to this work with: Hila Asraf, Rachel Avunie-Masala

Affiliation Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
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Rachel Avunie-Masala ,

Contributed equally to this work with: Hila Asraf, Rachel Avunie-Masala

Affiliation Department of Chemistry, Faculty of Natural Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
⨯
Michal Hershfinkel,

Affiliation Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
⨯
Larisa Gheber

* E-mail: lgheber@bgu.ac.il

Affiliations Department of Chemistry, Faculty of Natural Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel, Ilse Katz Institute for Nanoscale Science and Technology, Ben-Gurion University of the Negev, Beer-Sheva, Israel
⨯

Mitotic Slippage and Expression of Survivin Are Linked to Differential Sensitivity of Human Cancer Cell-Lines to the Kinesin-5 Inhibitor Monastrol

Hila Asraf,
Rachel Avunie-Masala,
Michal Hershfinkel,
Larisa Gheber

Published: June 2, 2015
https://doi.org/10.1371/journal.pone.0129255

About the Authors

Hila Asraf

Contributed equally to this work with: Hila Asraf, Rachel Avunie-Masala

Affiliation Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel

Rachel Avunie-Masala

Contributed equally to this work with: Hila Asraf, Rachel Avunie-Masala

Affiliation Department of Chemistry, Faculty of Natural Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel

Michal Hershfinkel

Affiliation Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel

Larisa Gheber

* E-mail: lgheber@bgu.ac.il

Affiliations Department of Chemistry, Faculty of Natural Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel, Ilse Katz Institute for Nanoscale Science and Technology, Ben-Gurion University of the Negev, Beer-Sheva, Israel

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HA RAM MH LG. Performed the experiments: HA RAM. Analyzed the data: HA RAM MH LG. Contributed reagents/materials/analysis tools: MH LG. Wrote the paper: MH LG.

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HT29 cells
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Cancer treatment
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Transfection
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Cyclins
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Apoptosis
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Microtubules
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Mitosis
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Hyperexpression techniques
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