About the Authors

Outi Vaarala

outi.vaarala@helsinki.fi

Affiliation Department of Vaccinations and Immune Protection, National Institute for Health and Welfare, Helsinki, Finland

Arja Vuorela

Affiliation Department of Vaccinations and Immune Protection, National Institute for Health and Welfare, Helsinki, Finland

Markku Partinen

Affiliation Helsinki Sleep Clinic, Vitalmed Research Centre Helsinki and Haartman Institute, University of Helsinki, Helsinki, Finland

Marc Baumann

Affiliation Meilahti Clinical Proteomics Core Facility, Institute of Biomedicine/Biochemistry and Developmental Biology, and NeuroMed Research Program, University of Helsinki, Helsinki, Finland

Tobias L. Freitag

Affiliation Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, Helsinki, Finland and Research Program Unit, Immunobiology, University of Helsinki, Helsinki, Finland

Seppo Meri

Affiliation Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, Helsinki, Finland and Research Program Unit, Immunobiology, University of Helsinki, Helsinki, Finland

Päivi Saavalainen

Affiliation Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, Helsinki, Finland and Research Program Unit, Immunobiology, University of Helsinki, Helsinki, Finland

Matti Jauhiainen

Affiliation National Institute for Health and Welfare, Public Health Genomics Research Unit, Biomedicum, Helsinki, Finland

Rabah Soliymani

Affiliation Meilahti Clinical Proteomics Core Facility, Institute of Biomedicine/Biochemistry and Developmental Biology, and NeuroMed Research Program, University of Helsinki, Helsinki, Finland

Turkka Kirjavainen

Affiliation Department of Pediatrics, Children’s Hospital, Helsinki University Hospital, Helsinki, Finland

Päivi Olsen

Affiliation Department of Child Neurology, Oulu University Hospital, Oulu, Finland

Outi Saarenpää-Heikkilä

Affiliation Department of Pediatrics, Tampere University Hospital, Tampere, Finland

Juha Rouvinen

Affiliation Department of Chemistry and Biocenter Kuopio, University of Eastern Finland, Joensuu, Finland

Merja Roivainen

Affiliation Department of Infectious Disease Surveillance and Control, National Institute for Health and Welfare, Helsinki, Finland

Hanna Nohynek

Affiliation Department of Vaccinations and Immune Protection, National Institute for Health and Welfare, Helsinki, Finland

Jukka Jokinen

Affiliation Department of Vaccinations and Immune Protection, National Institute for Health and Welfare, Helsinki, Finland

Ilkka Julkunen

Affiliations Department of Infectious Disease Surveillance and Control, National Institute for Health and Welfare, Helsinki, Finland, Department of Virology, University of Turku, Turku, Finland

Terhi Kilpi

Affiliation Department of Vaccinations and Immune Protection, National Institute for Health and Welfare, Helsinki, Finland

Competing Interests

HN received honoraria for technical consultancy from GlaxoSmithKline (GSK), and Pfizer for development of pneumococcal conjugate vaccines. JJ is co-investigator of a nationwide effectiveness study of the ten-valent pneumococcal conjugate vaccine mainly funded by GlaxoSmithKline. MP has been consultant for Bioprojet and UCB Pharma and received funding support and honoraries for lecturing from Bioprojet, GSK, Cephalon, and Leiras/Takeda. T. Kilpi is principal investigator of a nationwide effectiveness study of the ten-valent pneumococcal conjugate vaccine mainly funded by GlaxoSmithKline, and her unit received funding for a clinical trial on the safety and immunogenicity of a prototype pandemic influenza vaccine from Solvay Pharmaceuticals. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials. All other authors confirm they have no conflicts of interest. This does not alter the authors’ adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: OV AV MB MJ JR TLF SM. Performed the experiments: OV AV MB MJ TLF IJ MR RS. Analyzed the data: OV AV PS MB MJ TLF JJ. Contributed reagents/materials/analysis tools: MP PO TK OSH. Wrote the paper: OV AV MB MJ JR TLF SM IJ TK HN JJ MP.