About the Authors
- Branden S. Moriarity
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Affiliations Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota, United States of America, Center for Genome Engineering and Institute of Human Genetics, University of Minnesota, Minneapolis, Minnesota, United States of America, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, United States of America
- Eric P. Rahrmann
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Affiliations Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota, United States of America, Center for Genome Engineering and Institute of Human Genetics, University of Minnesota, Minneapolis, Minnesota, United States of America, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, United States of America
- Dominic A. Beckmann
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Affiliations Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota, United States of America, Center for Genome Engineering and Institute of Human Genetics, University of Minnesota, Minneapolis, Minnesota, United States of America, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, United States of America
- Caitlin B. Conboy
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Affiliations Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota, United States of America, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, United States of America
- Adrienne L. Watson
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Affiliations Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota, United States of America, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, United States of America
- Daniel F. Carlson
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Affiliations Center for Genome Engineering and Institute of Human Genetics, University of Minnesota, Minneapolis, Minnesota, United States of America, Department of Animal Science, University of Minnesota, Minneapolis, Minnesota, United States of America, Recombinetics, Inc., Saint Paul, Minnesota, United States of America
- Erik R. Olson
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Affiliation Discovery Genomics, Inc, Minneapolis, Minnesota, United States of America
- Kendra A. Hyland
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Affiliation Discovery Genomics, Inc, Minneapolis, Minnesota, United States of America
- Scott C. Fahrenkrug
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Affiliations Center for Genome Engineering and Institute of Human Genetics, University of Minnesota, Minneapolis, Minnesota, United States of America, Department of Animal Science, University of Minnesota, Minneapolis, Minnesota, United States of America, Recombinetics, Inc., Saint Paul, Minnesota, United States of America
- R. Scott McIvor
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Affiliations Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota, United States of America, Center for Genome Engineering and Institute of Human Genetics, University of Minnesota, Minneapolis, Minnesota, United States of America, Discovery Genomics, Inc, Minneapolis, Minnesota, United States of America
- David A. Largaespada
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* E-mail:larga002@umn.edu
Affiliations Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota, United States of America, Center for Genome Engineering and Institute of Human Genetics, University of Minnesota, Minneapolis, Minnesota, United States of America, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, United States of America, Discovery Genomics, Inc, Minneapolis, Minnesota, United States of America, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, United States of America
Competing Interests
R.S.M is a founder and managing employee of Discovery Genomics, Inc. (DGI), including stock and options. K.H. and E.O. are employees of DGI with stock options. D.A.L. is a founder of DGI with stock. D.A.L. is a founder of NeoClone Biotechnology, Inc. with stock. D.F.C and S.F are currently an employee of and CEO, respectfully, of Recombinetics, Inc. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.
Author Contributions
Conceived and designed the experiments: BSM DAL RSM. Performed the experiments: BSM DAB EPR CBC ALW KAH. Analyzed the data: BSM DAB EPR. Contributed reagents/materials/analysis tools: DFC SCF ERO. Wrote the paper: BSM.