About the Authors

Robert S. Wallis

rswallis@gmail.com

Current address: Aurum Institute, Johannesburg, South Africa

Affiliation Formerly Pfizer Inc, Groton, Connecticut, United States of America

Rodney Dawson

Affiliation University of Cape Town, Cape Town, South Africa

Sven O. Friedrich

Affiliation Division of Medical Physiology, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa

Amour Venter

Affiliation Medical Research Council Centre for Molecular and Cellular Biology, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa

Darcy Paige

Affiliation Pfizer, Groton, Connecticut, United States of America

Tong Zhu

Affiliation Pfizer, Groton, Connecticut, United States of America

Annette Silvia

Affiliation Pfizer, Groton, Connecticut, United States of America

Jason Gobey

Affiliation Pfizer, Groton, Connecticut, United States of America

Craig Ellery

Affiliation Pfizer, Groton, Connecticut, United States of America

Yao Zhang

Affiliation Pfizer, Groton, Connecticut, United States of America

Kathleen Eisenach

Affiliation University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America

Paul Miller

Current address: Infection Innovative Medicines Unit, AstraZeneca Pharmaceuticals, Waltham, Massachusetts, United States of America

Affiliation Formerly Pfizer Inc, Groton, Connecticut, United States of America

Andreas H. Diacon

Affiliation Division of Medical Physiology, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa

Competing Interests

The authors have read the journal's policy and have the following conflicts: RSW, DP, TZ, AS, JG, CE, YZ and PM are/were Pfizer employees, and/or shareholders at the time the study was conducted, whose company funded this study. KE of the University of Arkansas was a paid consultant to Pfizer Inc in regards to the study design. Rights to sutezolid were acquired by Sequella, Inc. in 2013. There are no further patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: RSW RD AV SF DP TZ AS JG CE YZ KE PM AHD. Performed the experiments: RD AV SF AHD. Analyzed the data: YZ TZ RSW. Contributed reagents/materials/analysis tools: RSW. Wrote the paper: RSW RD AV SF DP TZ AS JG CE YZ KE PM AHD.