About the Authors

Blake A. Jacobson

Affiliation Department of Medicine, University of Minnesota, Minneapolis, Minnesota, United States of America

Saritha C. Thumma

Affiliation Department of Medicine, University of Minnesota, Minneapolis, Minnesota, United States of America

Joseph Jay-Dixon

Affiliation Department of Medicine, University of Minnesota, Minneapolis, Minnesota, United States of America

Manish R. Patel

Affiliation Department of Medicine, University of Minnesota, Minneapolis, Minnesota, United States of America

K. Dubear Kroening

Affiliation Department of Biological Sciences, University of Wisconsin-Fox Valley, Menasha, Wisconsin, United States of America

Marian G. Kratzke

Affiliation Research Service, Minneapolis Veterans Affairs Medical Center, Minneapolis, Minnesota, United States of America

Ryan G. Etchison

Affiliation Department of Medicine, University of Minnesota, Minneapolis, Minnesota, United States of America

Bruce W. Konicek

Affiliation Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, United States of America

Jeremy R. Graff

Affiliation Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, United States of America

Robert A. Kratzke

kratz003@umn.edu

Affiliation Department of Medicine, University of Minnesota, Minneapolis, Minnesota, United States of America

Competing Interests

Potential conflicts of interest are that J.R. Graff and B.W. Konicek are employees of Eli Lilly and Company and are also on the patent for 4EASO (LY2275796). US Pat. No. 7601700 is the patent for LY2275796 with the title “modulation of eIF4E expression”. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials. All other authors declare no potential conflicts of interest.

Author Contributions

Conceived and designed the experiments: BAJ SCT MRP BWK JRG RAK. Performed the experiments: BAJ SCT JJD KDK MGK RGE. Analyzed the data: BAJ SCT MRP BWK JRG RAK JJD KDK MGK RGE. Contributed reagents/materials/analysis tools: BWK JRG RAK. Wrote the manuscript: BAJ MRP JRG RAK. Reviewed and approved the final version of the manuscript: BAJ SCT MRP BWK JRG RAK JJD KDK MGK RGE.