Sub-Domains of Ricin’s B Subunit as Targets of Toxin Neutralizing and Non-Neutralizing Monoclonal Antibodies

Anastasiya Yermakova; David J. Vance; Nicholas J. Mantis

doi:10.1371/journal.pone.0044317

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Peer-reviewed

Research Article

Sub-Domains of Ricin’s B Subunit as Targets of Toxin Neutralizing and Non-Neutralizing Monoclonal Antibodies

Anastasiya Yermakova,

Affiliations Division of Infectious Disease, Wadsworth Center, New York State Department of Health, Albany, New York, United States of America, Department of Biomedical Sciences, University at Albany School of Public Health, Albany, New York, United States of America
⨯
David J. Vance,

Affiliation Division of Infectious Disease, Wadsworth Center, New York State Department of Health, Albany, New York, United States of America
⨯
Nicholas J. Mantis

* E-mail: nmantis@wadsworth.org

Affiliations Division of Infectious Disease, Wadsworth Center, New York State Department of Health, Albany, New York, United States of America, Department of Biomedical Sciences, University at Albany School of Public Health, Albany, New York, United States of America
⨯

Sub-Domains of Ricin’s B Subunit as Targets of Toxin Neutralizing and Non-Neutralizing Monoclonal Antibodies

Anastasiya Yermakova,
David J. Vance,
Nicholas J. Mantis

Published: September 11, 2012
https://doi.org/10.1371/journal.pone.0044317

About the Authors

Anastasiya Yermakova

Affiliations Division of Infectious Disease, Wadsworth Center, New York State Department of Health, Albany, New York, United States of America, Department of Biomedical Sciences, University at Albany School of Public Health, Albany, New York, United States of America

David J. Vance

Affiliation Division of Infectious Disease, Wadsworth Center, New York State Department of Health, Albany, New York, United States of America

Nicholas J. Mantis

* E-mail: nmantis@wadsworth.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AY DJV NJM. Performed the experiments: AY DJV. Analyzed the data: AY DJV NJM. Wrote the paper: AY DJV NJM.

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Ricin
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Phage display
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Toxins
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Vero cells
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Hybridomas
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B cells
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Apoptosis
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Enzyme-linked immunoassays
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