Mutually Positive Regulatory Feedback Loop between Interferons and Estrogen Receptor-α in Mice: Implications for Sex Bias in Autoimmunity

Ravichandran Panchanathan; Hui Shen; Xiang Zhang; Shuk-mei Ho; Divaker Choubey

doi:10.1371/journal.pone.0010868

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Peer-reviewed

Research Article

Mutually Positive Regulatory Feedback Loop between Interferons and Estrogen Receptor-α in Mice: Implications for Sex Bias in Autoimmunity

Ravichandran Panchanathan,

Affiliations Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio, United States of America, Cincinnati Veterans Affairs Medical Center, Cincinnati, Ohio, United States of America
⨯
Hui Shen,

Affiliations Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio, United States of America, Cincinnati Veterans Affairs Medical Center, Cincinnati, Ohio, United States of America
⨯
Xiang Zhang,

Affiliation Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio, United States of America
⨯
Shuk-mei Ho,

Affiliation Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio, United States of America
⨯
Divaker Choubey

* E-mail: Divaker.choubey@uc.edu

Affiliations Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio, United States of America, Cincinnati Veterans Affairs Medical Center, Cincinnati, Ohio, United States of America
⨯

Mutually Positive Regulatory Feedback Loop between Interferons and Estrogen Receptor-α in Mice: Implications for Sex Bias in Autoimmunity

Ravichandran Panchanathan,
Hui Shen,
Xiang Zhang,
Shuk-mei Ho,
Divaker Choubey

Published: May 28, 2010
https://doi.org/10.1371/journal.pone.0010868

About the Authors

Ravichandran Panchanathan

Affiliations Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio, United States of America, Cincinnati Veterans Affairs Medical Center, Cincinnati, Ohio, United States of America

Hui Shen

Xiang Zhang

Affiliation Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio, United States of America

Shuk-mei Ho

Affiliation Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio, United States of America

Divaker Choubey

* E-mail: Divaker.choubey@uc.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RP DC. Performed the experiments: RP HS XZ. Analyzed the data: HS XZ SmH DC. Contributed reagents/materials/analysis tools: SmH. Wrote the paper: RP DC.

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Systemic lupus erythematosus
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Mouse models
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DNA transcription
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Messenger RNA
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Estrogens
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Interferons
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Gene expression
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Transfection
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