SIRT1 Inhibition Alleviates Gene Silencing in Fragile X Mental Retardation Syndrome

Rea Biacsi; Daman Kumari; Karen Usdin

doi:10.1371/journal.pgen.1000017

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Open Access

Peer-reviewed

Research Article

SIRT1 Inhibition Alleviates Gene Silencing in Fragile X Mental Retardation Syndrome

Rea Biacsi,

Affiliations Section on Genomic Structure and Function, Laboratory of Molecular and Cellular Biology, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America, Doctorate School of Biology, Classical and Molecular Genetics Branch, Department of Genetics, Eötvös Lóránd University, Budapest, Hungary
⨯
Daman Kumari,

Affiliation Section on Genomic Structure and Function, Laboratory of Molecular and Cellular Biology, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Karen Usdin

* E-mail: ku@helix.nih.gov

Affiliation Section on Genomic Structure and Function, Laboratory of Molecular and Cellular Biology, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯

SIRT1 Inhibition Alleviates Gene Silencing in Fragile X Mental Retardation Syndrome

Rea Biacsi,
Daman Kumari,
Karen Usdin

Published: March 14, 2008
https://doi.org/10.1371/journal.pgen.1000017

About the Authors

Rea Biacsi

Affiliations Section on Genomic Structure and Function, Laboratory of Molecular and Cellular Biology, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America, Doctorate School of Biology, Classical and Molecular Genetics Branch, Department of Genetics, Eötvös Lóránd University, Budapest, Hungary

Daman Kumari

Affiliation Section on Genomic Structure and Function, Laboratory of Molecular and Cellular Biology, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

Karen Usdin

* E-mail: ku@helix.nih.gov

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RB DK KU. Performed the experiments: RB. Analyzed the data: RB DK KU. Wrote the paper: KU.

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DNA methylation
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Polymerase chain reaction
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Histones
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Immunoprecipitation
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Acetylation
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Fibroblasts
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DNA
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Gene expression
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