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Transfer Entropy Reconstruction and Labeling of Neuronal Connections from Simulated Calcium Imaging

Figure 2

Signal conditioning.

A Separation of the signal in two regimes according to the conditioning level (dotted line), a first one that encompasses the low activity events (red curves), and a second one that includes the bursting regimes only (blue). The same conditioning procedure is applied in both “E–only” networks (left) and in “E+I” ones (right). B Receiver Operating Characteristic (ROC) curves quantify the accuracy of reconstruction and its sensitivity on conditioning. Functional networks are generated by including links with a calculated GTE score exceeding an arbitrary threshold. ROC curves plot then the fraction of true and false positives in the functional networks inferred for every possible threshold. For “E–only” networks (left) and “E+I” networks (right), the red curves show the goodness of the reconstruction after applying the conditioning procedure. Blue curves illustrate the reconstruction performance without conditioning. The ROC curves show that the conditioning procedure significantly improves reconstruction performance. ROC curves were averaged over different network realizations (95% confidence intervals shown).

Figure 2

doi: https://doi.org/10.1371/journal.pone.0098842.g002