Altered Serotonin, Dopamine and Norepinepherine Levels in 15q Duplication and Angelman Syndrome Mouse Models
Figure 1
E6-AP/Ube3a expression levels are decreased in Ube3a deficient mice in the hippocampus and cerebellum and increased in maternal 7p duplication animals.
Ube3a protein shows significant reduction (>80%; p≤0.05 and n = 3) in Ube3a deficient mice and a 75% increase in 7p maternal duplication animals (p≤0.05 and n = 3). A slight increase in Ube3a expression was also observed in 7p paternal duplication animals compared to wild type animals but did not reach significance. *p≤0.05 compared to wild type.