About the Authors
- Yutaka Takebe
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Affiliation AIDS Research Center, National Institute of Infectious Diseases, Tokyo, Japan
- Carrie J. Saucedo
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Affiliation Molecular Targets Laboratory, SAIC-Frederick, Frederick, Maryland, United States of America
- Garry Lund
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Affiliation KMT Hepatech, Edmonton, Alberta, Canada
- Rie Uenishi
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Affiliation AIDS Research Center, National Institute of Infectious Diseases, Tokyo, Japan
- Saiki Hase
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Affiliation AIDS Research Center, National Institute of Infectious Diseases, Tokyo, Japan
- Takayo Tsuchiura
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Affiliation AIDS Research Center, National Institute of Infectious Diseases, Tokyo, Japan
- Norman Kneteman
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Affiliation KMT Hepatech, Edmonton, Alberta, Canada
- Koreen Ramessar
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Affiliation Molecular Targets Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, United States of America
- D. Lorne J. Tyrrell
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Affiliation KMT Hepatech, Edmonton, Alberta, Canada
- Masayuki Shirakura
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Current address: Influenza Research Center, National Institute of Infectious Diseases, Tokyo, Japan
Affiliation Virology II, National Institute of Infectious Diseases, Tokyo, Japan
- Takaji Wakita
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Affiliation Virology II, National Institute of Infectious Diseases, Tokyo, Japan
- James B. McMahon
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Affiliation Molecular Targets Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, United States of America
- Barry R. O'Keefe
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* E-mail: okeefeba@mail.nih.gov
Affiliation Molecular Targets Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, United States of America
Competing Interests
The patents for both Griffithsin and Scytovirin are wholly owned by the U.S. Government. Drs. O'Keefe and McMahon are named inventors on patents for both proteins.Norman Kneteman, Garry Lund and Lorne Tyrrell are affiliated to KMT Hepatech which is a contract research organization funded by NIAID for hepatitis C studies with no competing interests. KMT Hepatech has no rights or interests in further developing the antiviral proteins griffithsin and scytovirin for commercial use. Their involvement in this manuscript does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.
Author Contributions
Conceived and designed the experiments: YT TT NK MS TW JBM BRO. Performed the experiments: YT CS GL RU SH KR DLT. Analyzed the data: YT CS GL RU SH TT NK KR DLT MS BRO. Contributed reagents/materials/analysis tools: YT NK MS TW BRO. Wrote the paper: YT GL NK JBM BRO.