About the Authors

Katsuhisa Matsuura

Affiliations Institute of Advanced Biomedical Engineering and Science, Tokyo Women’s Medical University, Tokyo, Japan, Department of Cardiology, Tokyo Women’s Medical University, Tokyo, Japan

Masanori Wada

Affiliation ABLE Corporation, Tokyo, Japan

Kanako Konishi

Affiliation Asahi Kasei Co. LTD., Tokyo, Japan

Michi Sato

Affiliation Asahi Kasei Co. LTD., Tokyo, Japan

Ushio Iwamoto

Affiliation Asahi Kasei Co. LTD., Tokyo, Japan

Yuko Sato

Affiliation Asahi Kasei Co. LTD., Tokyo, Japan

Aki Tachibana

Affiliation ABLE Corporation, Tokyo, Japan

Tetsutaro Kikuchi

Affiliations Institute of Advanced Biomedical Engineering and Science, Tokyo Women’s Medical University, Tokyo, Japan, CellSeed Inc., Tokyo, Japan

Takahiro Iwamiya

Affiliation Institute of Advanced Biomedical Engineering and Science, Tokyo Women’s Medical University, Tokyo, Japan

Tatsuya Shimizu

Affiliation Institute of Advanced Biomedical Engineering and Science, Tokyo Women’s Medical University, Tokyo, Japan

Jun K. Yamashita

Affiliation Laboratory of Stem Cell Differentiation, Stem Cell Research Center, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan

Masayuki Yamato

Affiliation Institute of Advanced Biomedical Engineering and Science, Tokyo Women’s Medical University, Tokyo, Japan

Nobuhisa Hagiwara

Affiliation Department of Cardiology, Tokyo Women’s Medical University, Tokyo, Japan

Teruo Okano

tokano@abmes.twmu.ac.jp

Affiliation Institute of Advanced Biomedical Engineering and Science, Tokyo Women’s Medical University, Tokyo, Japan

Competing Interests

The authors have read the journal’s policy and have the following conflicts. This research is fully granted by the Japan Society for the Promotion of Science (JSPS*) through the “Funding Program for World-Leading Innovative R&D on Science and Technology (FIRST Program),” initiated by the Council for Science and Technology Policy (CSTP). ABLE Corporation, Asahi Kasei Co. LTD and CellSeed Inc. have participated in the research as a collaborating institution, commissioned by the operational support institution of the research, Japan Science and Technology Agency (JST*). Although Tatsuya Shimizu and Masayuki Yamato are consultants for CellSeed, Inc., and Teruo Okano is an investor in CellSeed, Inc., this does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials. *JSPS is an independent administrative institution, established by way of a national law for the purpose of contributing to the advancement of science in all fields of the natural and social sciences and the humanities. *JST is an integrated organization of science and technology in Japan that establishes an infrastructure for the entire process from the creation of knowledge to the return the society.

Author Contributions

Conceived and designed the experiments: KM. Performed the experiments: KM MW MS KK UI YS AT TK TI. Analyzed the data: KM MW UI TS. Contributed reagents/materials/analysis tools: JKY. Wrote the paper: KM. Supervision: TS MY NH TO.