Selective Deletion of the A1 Adenosine Receptor Abolishes Heart-Rate Slowing Effects of Intravascular Adenosine In Vivo

Michael Koeppen; Tobias Eckle; Holger K. Eltzschig

doi:10.1371/journal.pone.0006784

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Peer-reviewed

Research Article

Selective Deletion of the A1 Adenosine Receptor Abolishes Heart-Rate Slowing Effects of Intravascular Adenosine In Vivo

Michael Koeppen ,

Contributed equally to this work with: Michael Koeppen, Tobias Eckle

Affiliation Mucosal Inflammation Program, Department of Anesthesiology and Perioperative Medicine, University of Colorado Denver, Aurora, Colorado, United States of America
⨯
Tobias Eckle ,

Contributed equally to this work with: Michael Koeppen, Tobias Eckle

Affiliation Mucosal Inflammation Program, Department of Anesthesiology and Perioperative Medicine, University of Colorado Denver, Aurora, Colorado, United States of America
⨯
Holger K. Eltzschig

* E-mail: holger.eltzschig@uchsc.edu

Affiliations Mucosal Inflammation Program, Department of Anesthesiology and Perioperative Medicine, University of Colorado Denver, Aurora, Colorado, United States of America, Department of Anesthesiology and Critical Care Medicine, Tübingen University Hospital, Tübingen, Germany
⨯

Selective Deletion of the A1 Adenosine Receptor Abolishes Heart-Rate Slowing Effects of Intravascular Adenosine In Vivo

Michael Koeppen,
Tobias Eckle,
Holger K. Eltzschig

Published: August 26, 2009
https://doi.org/10.1371/journal.pone.0006784

About the Authors

Michael Koeppen

Contributed equally to this work with: Michael Koeppen, Tobias Eckle

Affiliation Mucosal Inflammation Program, Department of Anesthesiology and Perioperative Medicine, University of Colorado Denver, Aurora, Colorado, United States of America

Tobias Eckle

Contributed equally to this work with: Michael Koeppen, Tobias Eckle

Affiliation Mucosal Inflammation Program, Department of Anesthesiology and Perioperative Medicine, University of Colorado Denver, Aurora, Colorado, United States of America

Holger K. Eltzschig

* E-mail: holger.eltzschig@uchsc.edu

Affiliations Mucosal Inflammation Program, Department of Anesthesiology and Perioperative Medicine, University of Colorado Denver, Aurora, Colorado, United States of America, Department of Anesthesiology and Critical Care Medicine, Tübingen University Hospital, Tübingen, Germany

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MK TE HKE. Performed the experiments: MK TE. Analyzed the data: MK TE HKE. Wrote the paper: MK HKE.

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Adenosine
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Heart rate
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Blood pressure
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Mouse models
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Bradycardia
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Catheters
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Genetics
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Caffeine
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