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Are you ready to submit your manuscript? Please review the submission guidelineseditorial and publishing policiesfigure guidelines, and table guidelines, and then refer to this checklist to ensure that you have gathered all the relevant information and that the manuscript is formatted appropriately.

All manuscripts must be submitted in the online submission system.

If you are unsure whether your work satisfies the basic requirements for publication in PLOS Computational Biology, we are happy to consider a Presubmission Inquiry. For more information, read the Presubmission Inquiry guidelines

Submission Checklist

License agreement

Have you read the license agreement? Are you able to sign it on behalf of all of the authors?

Publication fees

Have you discussed the publication fees with your co-authors? Publication fees are US$2250 per manuscript and will be billed upon acceptance. Editors and reviewers have no access to payment information, and hence inability to pay will not influence the decision to publish a paper.

Collection submissions

If you were invited to submit your paper to a PLOS Special Collection, have you reviewed the terms of submission and publication charges for PLOS Special Collections, and are you prepared to adhere to them?


Have you prepared a statement indicating who funded the study, and the role of the funding agency in conducting the study and in preparing the manuscript? You will be asked to enter this into the relevant section of the submission form.

Author list

Are all authors aware of, and do they approve of, the submission of the manuscript, its content, authorship, and the order of authorship?

Do you have the following information for all authors?

  • First Name, Middle Names/Initials, Last Name
  • Work Affiliations
  • Email Address
  • Any Competing Interests
  • Financial Disclosure/Funding Information
  • Author Contributions

Reporting guidelines

Do all authors agree to abide by established study guidelines (MIAME, CONSORT, STROBE, etc.)?

Human and animal research

If your article includes human or animal research, have you read and followed our policies on human subjects research and animal research, which contain further information on the Declaration of Helsinki and The use of non-human primates in research (PDF)?

For research involving vertebrates please note, as part of the ethics statement, the guidelines followed and the committee that approved of the methods employed.


Have you confirmed that anyone named in the Acknowledgments section agrees to being so named?

Cover letter

Have you prepared a cover letter explaining why you consider this manuscript suitable for publication in PLOS Computational Biology

Related manuscripts

Are related manuscripts by any of the authors submitted or in press elsewhere? If so, are you prepared to provide a copy of each to accompany your submission?

Suggested editors

Have you identified potential editors who would be qualified to handle your submission? See the full Editorial Board list for more information, being mindful of any potential competing interests

Suggested reviewers

Have you identified at least four potential reviewers whose email addresses you can provide? Please ensure that you are aware of our competing interests policy when making these suggestions, and do not suggest colleagues who may have any of these conflicts.

Article file

Article file in DOC or RTF format, prepared per the submission guidelines. If you prepared your article using LaTeX, you should upload the file in PDF format for use during the editorial/review process. If the article is accepted for publication, your .tex files will be required. Please consult our LaTeX guidelines for a list of what will be required.

PLOS Computational Biology will accept initial submissions of manuscripts in a single PDF file including text and figures. If you are submitting a  revised manuscript, you must upload separate files for your text, figures, and supporting information before your submission can be passed back to the editors.


Include a full title (no more than 150 characters) and short title (no more than 50 characters)

Author summary

Include an Author Summary (no more than 200 words).


Include an Abstract of no more than 300 words.


Deposition of all appropriate datasets, images, and information in the relevant repositories or submission of undeposited data as supporting information files.

Accession numbers

Accession numbers for genes, proteins, mutants, diseases, etc. in parentheses after first use throughout the manuscript file


Standard nomenclature used throughout the manuscript file.


Non-standard abbreviations defined upon first use in the text.

Figures and tables

All figures and tables called out in the manuscript in ascending numeric order upon first appearance.

Original figure files uploaded as EPS or high-resolution (300 ppi – 600 ppi) TIFF format. If any of your figures are under copyright, please notify the journal office.


Use of PLOS style for references.

Supporting information

Any supporting information files should fall into one of the following categories: Dataset, Figure, Table, Text, Protocol, Audio, or Video. Checklist should be used for consensus guidelines for trials.

Each supporting information file must be uploaded separately. The numbered title and caption for each supporting information file should be entered into the appropriate fields in the online submission system with the appropriate formatting.

We recommend that you upload all your files in one step by creating a single .zip file, which the submission system will automatically unpack.

Revised Manuscripts

Are you submitting a revision? Read the guidelines for revised manuscripts.


Please contact if you have any questions.