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Open Access

Peer-reviewed

Research Article

Disruption of the Circadian Clock in Mice Increases Intestinal Permeability and Promotes Alcohol-Induced Hepatic Pathology and Inflammation

  • Keith C. Summa ,

    Contributed equally to this work with: Keith C. Summa, Robin M. Voigt, Fred W. Turek, Ali Keshavarzian

    ksumma@fsm.northwestern.edu

    Affiliations Center for Sleep and Circadian Biology, Department of Neurobiology, Northwestern University, Evanston, Illinois, United States of America, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America

    ⨯
  • Robin M. Voigt ,

    Contributed equally to this work with: Keith C. Summa, Robin M. Voigt, Fred W. Turek, Ali Keshavarzian

    Affiliation Division of Digestive Diseases and Nutrition, Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois, United States of America

    ⨯
  • Christopher B. Forsyth,

    Affiliations Division of Digestive Diseases and Nutrition, Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois, United States of America, Department of Biochemistry, Rush University Medical Center, Chicago, Illinois, United States of America

    ⨯
  • Maliha Shaikh,

    Affiliation Division of Digestive Diseases and Nutrition, Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois, United States of America

    ⨯
  • Kate Cavanaugh,

    Affiliation Center for Sleep and Circadian Biology, Department of Neurobiology, Northwestern University, Evanston, Illinois, United States of America

    ⨯
  • Yueming Tang,

    Affiliation Division of Digestive Diseases and Nutrition, Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois, United States of America

    ⨯
  • Martha Hotz Vitaterna,

    Affiliation Center for Sleep and Circadian Biology, Department of Neurobiology, Northwestern University, Evanston, Illinois, United States of America

    ⨯
  • Shiwen Song,

    Affiliation American Society for Clinical Pathology, Chicago, Illinois, United States of America

    ⨯
  • Fred W. Turek ,

    Contributed equally to this work with: Keith C. Summa, Robin M. Voigt, Fred W. Turek, Ali Keshavarzian

    Affiliation Center for Sleep and Circadian Biology, Department of Neurobiology, Northwestern University, Evanston, Illinois, United States of America

    ⨯
  • Ali Keshavarzian

    Contributed equally to this work with: Keith C. Summa, Robin M. Voigt, Fred W. Turek, Ali Keshavarzian

    Affiliations Division of Digestive Diseases and Nutrition, Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois, United States of America, Department of Pharmacology, Rush University Medical Center, Chicago, Illinois, United States of America, Department of Molecular Biophysics and Physiology, Rush University Medical Center, Chicago, Illinois, United States of America, Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands

    ⨯

Disruption of the Circadian Clock in Mice Increases Intestinal Permeability and Promotes Alcohol-Induced Hepatic Pathology and Inflammation

  • Keith C. Summa, 
  • Robin M. Voigt, 
  • Christopher B. Forsyth, 
  • Maliha Shaikh, 
  • Kate Cavanaugh, 
  • Yueming Tang, 
  • Martha Hotz Vitaterna, 
  • Shiwen Song, 
  • Fred W. Turek, 
  • Ali Keshavarzian
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