Upregulation of Inflammatory Genes and Downregulation of Sclerostin Gene Expression Are Key Elements in the Early Phase of Fragility Fracture Healing

• Joana Caetano-Lopes,

  Affiliation Rheumatology Research Unit, Faculdade de Medicina da Universidade de Lisboa, Instituto de Medicina Molecular, Lisbon, Portugal

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• Ana Lopes,

  Affiliation Rheumatology Research Unit, Faculdade de Medicina da Universidade de Lisboa, Instituto de Medicina Molecular, Lisbon, Portugal

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• Ana Rodrigues,

  Affiliations Rheumatology Research Unit, Faculdade de Medicina da Universidade de Lisboa, Instituto de Medicina Molecular, Lisbon, Portugal, Serviço de Reumatologia e Doenças Ósseas Metabólicas, Hospital de Santa Maria, Lisbon, Portugal

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• Diana Fernandes,

  Affiliation Rheumatology Research Unit, Faculdade de Medicina da Universidade de Lisboa, Instituto de Medicina Molecular, Lisbon, Portugal

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• Inês P. Perpétuo,

  Affiliation Rheumatology Research Unit, Faculdade de Medicina da Universidade de Lisboa, Instituto de Medicina Molecular, Lisbon, Portugal

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• Teresa Monjardino,

  Affiliations Department of Hygiene and Epidemiology, University of Porto Medical School, Porto, Portugal, Institute of Public Health, University of Porto, Porto, Portugal

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• Raquel Lucas,

  Affiliations Department of Hygiene and Epidemiology, University of Porto Medical School, Porto, Portugal, Institute of Public Health, University of Porto, Porto, Portugal

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• Jacinto Monteiro,

  Affiliation Orthopaedics Department, Hospital de Santa Maria, Lisbon, Portugal

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• Yrjö T. Konttinen,

  Affiliations Department of Medicine, University of Helsinki, Helsinki, Finland, ORTON Orthopaedic Hospital of the Invalid Foundation, Helsinki, Finland, COXA Hospital for Joint Replacement, Tampere, Finland

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• Helena Canhão ,

  Contributed equally to this work with: Helena Canhão, João E. Fonseca

  Affiliations Rheumatology Research Unit, Faculdade de Medicina da Universidade de Lisboa, Instituto de Medicina Molecular, Lisbon, Portugal, Serviço de Reumatologia e Doenças Ósseas Metabólicas, Hospital de Santa Maria, Lisbon, Portugal

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• João E. Fonseca

  Contributed equally to this work with: Helena Canhão, João E. Fonseca

  * E-mail: jefonseca@netcabo.pt

  Affiliations Rheumatology Research Unit, Faculdade de Medicina da Universidade de Lisboa, Instituto de Medicina Molecular, Lisbon, Portugal, Serviço de Reumatologia e Doenças Ósseas Metabólicas, Hospital de Santa Maria, Lisbon, Portugal

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