Role of riboflavin deficiency in malaria pathophysiology

Shweta Sharma, Arathy Ramachandran, Amit Sharma

PLOS Pathogens: published March 1, 2024 | https://doi.org/10.1371/journal.ppat.1011991

Impact of interkingdom microbial interactions in the vaginal tract

Shirli Cohen, Kyla S. Ost, Kelly S. Doran

PLOS Pathogens: published March 8, 2024 | https://doi.org/10.1371/journal.ppat.1012018

Recent advances in the treatment of Ebola disease: A brief overview

L’Emir Wassim El Ayoubi, Omar Mahmoud, Johnny Zakhour, Souha S. Kanj

PLOS Pathogens: published March 15, 2024 | https://doi.org/10.1371/journal.ppat.1012038

Renaming Candida glabrata—A case of taxonomic purity over clinical and public health pragmatism

David W. Denning

PLOS Pathogens: published March 15, 2024 | https://doi.org/10.1371/journal.ppat.1012055

Koch’s curse: How models of extreme pathology bias studies of host–pathogen interactions

Kalyan K. Dewan, Eric T. Harvill

PLOS Pathogens: published March 15, 2024 | https://doi.org/10.1371/journal.ppat.1011997

Ebola virus disease sequelae and viral persistence in animal models: Implications for the future

Olivia Durant, Andrea Marzi

PLOS Pathogens: published March 21, 2024 | https://doi.org/10.1371/journal.ppat.1012065

Behind the scenes: Centromere-driven genomic innovations in fungal pathogens

Aswathy Narayanan, Md. Hashim Reza, Kaustuv Sanyal

PLOS Pathogens: published March 28, 2024 | https://doi.org/10.1371/journal.ppat.1012080

The many faces of Candida auris: Phenotypic and strain variation in an emerging pathogen

Darian J. Santana, Guolei Zhao, Teresa R. O’Meara

PLOS Pathogens: published March 1, 2024 | https://doi.org/10.1371/journal.ppat.1012011

Small molecule mediators of host-T. cruzi-environment interactions in Chagas disease

Godwin Kwakye-Nuako, Caitlyn E. Middleton, Laura-Isobel McCall

PLOS Pathogens: published March 8, 2024 | https://doi.org/10.1371/journal.ppat.1012012

The impact of HTLV-1 expression on the 3D structure and expression of host chromatin

Hiroko Yaguchi, Anat Melamed, Saumya Ramanayake, Helen Kiik, Aviva Witkover, Charles R. M. Bangham

PLOS Pathogens: published March 1, 2024 | https://doi.org/10.1371/journal.ppat.1011716

Candida albicans translocation through the intestinal epithelial barrier is promoted by fungal zinc acquisition and limited by NFκB-mediated barrier protection

Jakob L. Sprague, Tim B. Schille, Stefanie Allert, Verena Trümper, Adrian Lier, Peter Großmann, Emily L. Priest, Antzela Tsavou, Gianni Panagiotou, Julian R. Naglik, Duncan Wilson, Sascha Schäuble, Lydia Kasper, Bernhard Hube

PLOS Pathogens: published March 1, 2024 | https://doi.org/10.1371/journal.ppat.1012031

Structure-guided design of VAR2CSA-based immunogens and a cocktail strategy for a placental malaria vaccine

Rui Ma, Nichole D. Salinas, Sachy Orr-Gonzalez, Brandi Richardson, Tarik Ouahes, Holly Torano, Bethany J. Jenkins, Thayne H. Dickey, Jillian Neal, Junhui Duan, Robert D. Morrison, Apostolos G. Gittis, Justin Y. A. Doritchamou, Irfan Zaidi, Lynn E. Lambert, Patrick E. Duffy, Niraj H. Tolia

PLOS Pathogens: published March 4, 2024 | https://doi.org/10.1371/journal.ppat.1011879

Rubisco small subunit (RbCS) is co-opted by potyvirids as the scaffold protein in assembling a complex for viral intercellular movement

Li Qin, Hongjun Liu, Peilan Liu, Lu Jiang, Xiaofei Cheng, Fangfang Li, Wentao Shen, Wenping Qiu, Zhaoji Dai, Hongguang Cui

PLOS Pathogens: published March 4, 2024 | https://doi.org/10.1371/journal.ppat.1012064

Comparative analysis of human, rodent and snake deltavirus replication

Pierre Khalfi, Zoé Denis, Joe McKellar, Giovanni Merolla, Carine Chavey, José Ursic-Bedoya, Lena Soppa, Leonora Szirovicza, Udo Hetzel, Jeremy Dufourt, Cedric Leyrat, Nora Goldmann, Kaku Goto, Eloi Verrier, Thomas F. Baumert, Dieter Glebe, Valérie Courgnaud, Damien Gregoire, Jussi Hepojoki, Karim Majzoub

PLOS Pathogens: published March 5, 2024 | https://doi.org/10.1371/journal.ppat.1012060

Multiple genetic loci influence vaccine-induced protection against Mycobacterium tuberculosis in genetically diverse mice

Sherry L. Kurtz, Richard E. Baker, Frederick J. Boehm, Chelsea C. Lehman, Lara R. Mittereder, Hamda Khan, Amy P. Rossi, Daniel M. Gatti, Gillian Beamer, Christopher M. Sassetti, Karen L. Elkins

PLOS Pathogens: published March 7, 2024 | https://doi.org/10.1371/journal.ppat.1012069

Streptolysin S is required for Streptococcus pyogenes nasopharyngeal and skin infection in HLA-transgenic mice

Blake A. Shannon, Jacklyn R. Hurst, Ronald S. Flannagan, Heather C. Craig, Aanchal Rishi, Katherine J. Kasper, Stephen W. Tuffs, David E. Heinrichs, John K. McCormick

PLOS Pathogens: published March 7, 2024 | https://doi.org/10.1371/journal.ppat.1012072

Modulation of nucleotide metabolism by picornaviruses

Lonneke V. Nouwen, Martijn Breeuwsma, Esther A. Zaal, Chris H. A. van de Lest, Inge Buitendijk, Marleen Zwaagstra, Pascal Balić, Dmitri V. Filippov, Celia R. Berkers, Frank J. M. van Kuppeveld

PLOS Pathogens: published March 8, 2024 | https://doi.org/10.1371/journal.ppat.1012036

Repeated sensitization of mice with microfilariae of Litomosoides sigmodontis induces pulmonary eosinophilia in an IL-33-dependent manner

Benjamin Lenz, Alexandra Ehrens, Jesuthas Ajendra, Frederic Risch, Joséphine Gal, Anna-Lena Neumann, Julia J. Reichwald, Wiebke Strutz, Henry J. McSorley, Coralie Martin, Achim Hoerauf, Marc P. Hübner

PLOS Pathogens: published March 8, 2024 | https://doi.org/10.1371/journal.ppat.1012071

Hepatitis B virus e antigen induces atypical metabolism and differentially regulates programmed cell deaths of macrophages

Yumei Li, Christine Wu, Jiyoung Lee, Qiqi Ning, Juhyeon Lim, Hyungjin Eoh, Sean Wang, Benjamin P. Hurrell, Omid Akbari, Jing-hsiung James Ou

PLOS Pathogens: published March 11, 2024 | https://doi.org/10.1371/journal.ppat.1012079

Candida auris undergoes adhesin-dependent and -independent cellular aggregation

Chloe Pelletier, Sophie Shaw, Sakinah Alsayegh, Alistair J. P. Brown, Alexander Lorenz

PLOS Pathogens: published March 11, 2024 | https://doi.org/10.1371/journal.ppat.1012076

Computationally inferred cell-type specific epigenome-wide DNA methylation analysis unveils distinct methylation patterns among immune cells for HIV infection in three cohorts

Xinyu Zhang, Ying Hu, Ral E. Vandenhoudt, Chunhua Yan, Vincent C. Marconi, Mardge H. Cohen, Zuoheng Wang, Amy C. Justice, Bradley E. Aouizerat, Ke Xu

PLOS Pathogens: published March 11, 2024 | https://doi.org/10.1371/journal.ppat.1012063

KSHV vIL-6 promotes SIRT3-induced deacetylation of SERBP1 to inhibit ferroptosis and enhance cellular transformation by inducing lipoyltransferase 2 mRNA degradation

Jing Zhou, Tianjiao Wang, Haoran Zhang, Jianhong Liu, Pengjun Wei, Ruoqi Xu, Qin Yan, Guochun Chen, Wan Li, Shou-Jiang Gao, Chun Lu

PLOS Pathogens: published March 12, 2024 | https://doi.org/10.1371/journal.ppat.1012082

Loxapine inhibits replication of hepatitis A virus in vitro and in vivo by targeting viral protein 2C

Mami Matsuda, Asuka Hirai-Yuki, Osamu Kotani, Michiyo Kataoka, Xin Zheng, Daisuke Yamane, Masaru Yokoyama, Koji Ishii, Masamichi Muramatsu, Ryosuke Suzuki

PLOS Pathogens: published March 13, 2024 | https://doi.org/10.1371/journal.ppat.1012091

Uncovering a hidden functional role of the XRE-cupin protein PsdR as a novel quorum-sensing regulator in Pseudomonas aeruginosa

Huifang Qiu, Yuanhao Li, Min Yuan, Huali Chen, Ajai A. Dandekar, Weijun Dai

PLOS Pathogens: published March 14, 2024 | https://doi.org/10.1371/journal.ppat.1012078

NIa-Pro of sugarcane mosaic virus targets Corn Cysteine Protease 1 (CCP1) to undermine salicylic acid-mediated defense in maize

Wen Yuan, Xi Chen, Kaitong Du, Tong Jiang, Mengfei Li, Yanyong Cao, Xiangdong Li, Gunther Doehlemann, Zaifeng Fan, Tao Zhou

PLOS Pathogens: published March 14, 2024 | https://doi.org/10.1371/journal.ppat.1012086

Subversion of selective autophagy for the biogenesis of tombusvirus replication organelles inhibits autophagy

Yuanrong Kang, Wenwu Lin, Peter D. Nagy

PLOS Pathogens: published March 14, 2024 | https://doi.org/10.1371/journal.ppat.1012085

Chikungunya virus infection disrupts MHC-I antigen presentation via nonstructural protein 2

Brian C. Ware, M. Guston Parks, Mariana O. L. da Silva, Thomas E. Morrison

PLOS Pathogens: published March 14, 2024 | https://doi.org/10.1371/journal.ppat.1011794

ALIX and TSG101 are essential for cellular entry and replication of two porcine alphacoronaviruses

Xiongnan Chen, Yifan Liang, Zhijun Weng, Chen Hu, Yunzhao Peng, Yingshuo Sun, Qi Gao, Zhao Huang, Shengqiu Tang, Lang Gong, Guihong Zhang

PLOS Pathogens: published March 15, 2024 | https://doi.org/10.1371/journal.ppat.1012103

Transposon sequencing reveals metabolic pathways essential for Mycobacterium tuberculosis infection

Alisha M. Block, Parker C. Wiegert, Sarah B. Namugenyi, Anna D. Tischler

PLOS Pathogens: published March 18, 2024 | https://doi.org/10.1371/journal.ppat.1011663

BAG6 inhibits influenza A virus replication by inducing viral polymerase subunit PB2 degradation and perturbing RdRp complex assembly

Yong Zhou, Tian Li, Yunfan Zhang, Nianzhi Zhang, Yuxin Guo, Xiaoyi Gao, Wenjing Peng, Sicheng Shu, Chuankuo Zhao, Di Cui, Honglei Sun, Yipeng Sun, Jinhua Liu, Jun Tang, Rui Zhang, Juan Pu

PLOS Pathogens: published March 18, 2024 | https://doi.org/10.1371/journal.ppat.1012110

Establishment of a lethal mouse model of emerging tick-borne orthonairovirus infections

Takuma Ariizumi, Koshiro Tabata, Yukari Itakura, Hiroko Kobayashi, William W. Hall, Michihito Sasaki, Hirofumi Sawa, Keita Matsuno, Yasuko Orba

PLOS Pathogens: published March 19, 2024 | https://doi.org/10.1371/journal.ppat.1012101

Polyubiquitylated rice stripe virus NS3 translocates to the nucleus to promote cytosolic virus replication via miRNA-induced fibrillin 2 upregulation

Lu Zhang, Yao Li, Jens H. Kuhn, Kun Zhang, Qisheng Song, Fang Liu

PLOS Pathogens: published March 20, 2024 | https://doi.org/10.1371/journal.ppat.1012112

An LIR motif in the Rift Valley fever virus NSs protein is critical for the interaction with LC3 family members and inhibition of autophagy

Kaylee Petraccione, Mohamed G. H. Ali, Normand Cyr, Haytham M. Wahba, Timothy Stocker, Maryna Akhrymuk, Ivan Akhrymuk, Lauren Panny, Nicole Bracci, Raphaël Cafaro, Danuta Sastre, Andrew Silberfarb, Paul O’Maille, James Omichinski, Kylene Kehn-Hall

PLOS Pathogens: published March 21, 2024 | https://doi.org/10.1371/journal.ppat.1012093

Virus specificity and nucleoporin requirements for MX2 activity are affected by GTPase function and capsid-CypA interactions

Bailey Layish, Ram Goli, Haley Flick, Szu-Wei Huang, Robert Z. Zhang, Mamuka Kvaratskhelia, Melissa Kane

PLOS Pathogens: published March 21, 2024 | https://doi.org/10.1371/journal.ppat.1011830

A genome-wide CRISPR screening uncovers that TOB1 acts as a key host factor for FMDV infection via both IFN and EGFR mediated pathways

Gaochuang Peng, Tianran Liu, Xiaolan Qi, Yuzhe Wang, Jingjing Ren, Jiangling Peng, Xuguang Du, Siyu Hu, Sen Wu, Yaofeng Zhao, Dan Li, Haixue Zheng

PLOS Pathogens: published March 21, 2024 | https://doi.org/10.1371/journal.ppat.1012104

Autoimmunity-associated allele of tyrosine phosphatase gene PTPN22 enhances anti-viral immunity

Robin C. Orozco, Kristi Marquardt, Isaraphorn Pratumchai, Anam Fatima Shaikh, Kerri Mowen, Alain Domissy, John R. Teijaro, Linda A. Sherman

PLOS Pathogens: published March 21, 2024 | https://doi.org/10.1371/journal.ppat.1012095

Deubiquitinating activity of SARS-CoV-2 papain-like protease does not influence virus replication or innate immune responses in vivo

Mariska van Huizen, Jonna R. Bloeme - ter Horst, Heidi L. M. de Gruyter, Paul P. Geurink, Gerbrand J. van der Heden van Noort, Robert C. M. Knaap, Tessa Nelemans, Natacha S. Ogando, Anouk A. Leijs, Nadya Urakova, Brian L. Mark, Eric J. Snijder, Sebenzile K. Myeni, Marjolein Kikkert

PLOS Pathogens: published March 25, 2024 | https://doi.org/10.1371/journal.ppat.1012100

Manipulating multi-level selection in a fungal entomopathogen reveals social conflicts and a method for improving biocontrol traits

Zoltan Erdos, David J. Studholme, Manmohan D. Sharma, David Chandler, Chris Bass, Ben Raymond

PLOS Pathogens: published March 25, 2024 | https://doi.org/10.1371/journal.ppat.1011775

Differential carbonic anhydrase activities control EBV-induced B-cell transformation and lytic cycle reactivation

Samaresh Malik, Joyanta Biswas, Purandar Sarkar, Subhadeep Nag, Chandrima Gain, Shatadru Ghosh Roy, Bireswar Bhattacharya, Dipanjan Ghosh, Abhik Saha

PLOS Pathogens: published March 26, 2024 | https://doi.org/10.1371/journal.ppat.1011998

Local-scale phylodynamics reveal differential community impact of SARS-CoV-2 in a metropolitan US county

Miguel I. Paredes, Amanda C. Perofsky, Lauren Frisbie, Louise H. Moncla, Pavitra Roychoudhury, Hong Xie, Shah A. Mohamed Bakhash, Kevin Kong, Isabel Arnould, Tien V. Nguyen, Seffir T. Wendm, Pooneh Hajian, Sean Ellis, Patrick C. Mathias, Alexander L. Greninger, Lea M. Starita, Chris D. Frazar, Erica Ryke, Weizhi Zhong, Luis Gamboa, Machiko Threlkeld, Jover Lee, Jeremy Stone, Evan McDermot, Melissa Truong, Jay Shendure, Hanna N. Oltean, Cécile Viboud, Helen Chu, Nicola F. Müller, Trevor Bedford

PLOS Pathogens: published March 26, 2024 | https://doi.org/10.1371/journal.ppat.1012117

The read-through transcription-mediated autoactivation circuit for virulence regulator expression drives robust type III secretion system 2 expression in Vibrio parahaemolyticus

Dhira Saraswati Anggramukti, Eiji Ishii, Andre Pratama, Mohamad Al Kadi, Tetsuya Iida, Toshio Kodama, Shigeaki Matsuda

PLOS Pathogens: published March 27, 2024 | https://doi.org/10.1371/journal.ppat.1012094

A clinically attenuated double-mutant of porcine reproductive and respiratory syndrome virus-2 that does not prompt overexpression of proinflammatory cytokines during co-infection with a secondary pathogen

Chia-Ming Su, Jineui Kim, Junyu Tang, Yu Fan Hung, Federico A. Zuckermann, Robert Husmann, Patrick Roady, Jiyoun Kim, Young-Min Lee, Dongwan Yoo

PLOS Pathogens: published March 28, 2024 | https://doi.org/10.1371/journal.ppat.1012128

A novel sORF gene mutant strain of Yersinia pestis vaccine EV76 offers enhanced safety and improved protection against plague

Xiao Guo, Youquan Xin, Zehui Tong, Shiyang Cao, Yuan Zhang, Gengshan Wu, Hongyan Chen, Tong Wang, Yajun Song, Qingwen Zhang, Ruifu Yang, Zongmin Du

PLOS Pathogens: published March 28, 2024 | https://doi.org/10.1371/journal.ppat.1012129

The Wolbachia WalE1 effector alters Drosophila endocytosis

MaryAnn Martin, Sergio López-Madrigal, Irene L. G. Newton

PLOS Pathogens: published March 28, 2024 | https://doi.org/10.1371/journal.ppat.1011245

Chronic viral infection impairs immune memory to a different pathogen

Cheng Yang, Zhicui Liu, Ying Yang, Luis J. Cocka, Yongguo Li, Weihong Zeng, Hao Shen

PLOS Pathogens: published March 28, 2024 | https://doi.org/10.1371/journal.ppat.1012113

A divergent protein kinase A regulatory subunit essential for morphogenesis of the human pathogen Leishmania

Renana Fischer Weinberger, Sabine Bachmaier, Veronica Ober, George B. Githure, Ramu Dandugudumula, Isabelle Q. Phan, Michal Almoznino, Eleni Polatoglou, Polina Tsigankov, Roni Nitzan Koren, Peter J. Myler, Michael Boshart, Dan Zilberstein

PLOS Pathogens: published March 29, 2024 | https://doi.org/10.1371/journal.ppat.1012073

Classical swine fever virus non-structural protein 5B hijacks host METTL14-mediated m⁶A modification to counteract host antiviral immune response

Jing Chen, Hui-xin Song, Jia-huan Hu, Ji-shan Bai, Xiao-han Li, Rui-cong Sun, Bing-qian Zhao, Mei-zhen Li, Bin Zhou

PLOS Pathogens: published March 29, 2024 | https://doi.org/10.1371/journal.ppat.1012130

Editorial Note: Bradykinin B₂ Receptors of Dendritic Cells, Acting as Sensors of Kinins Proteolytically Released by Trypanosoma cruzi, Are Critical for the Development of Protective Type-1 Responses

The PLOS Pathogens Editors

PLOS Pathogens: published March 11, 2024 | https://doi.org/10.1371/journal.ppat.1012070

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1. Bradykinin B₂ Receptors of Dendritic Cells, Acting as Sensors of Kinins Proteolytically Released by Trypanosoma cruzi, Are Critical for the Development of Protective Type-1 Responses