February 17, 2023
Image credit: Hawaii Dept. of Health
02/23/2023
Research Article
This study investigates how Bordetella pertussis, the pathogen responsible for whooping cough, forms structured biofilms in human bronchial epithelial cells. The model presented reveals the nature of ECM and bacterial determinants required for biofilm formation on primary human airway cells.
Image credit: Fullen et al
Current Issue February 2023
02/14/2023
Research Article
The impacts of transposable elements, engines of evolution, are multifaceted but vulnerable to pathogens, who mutate or silence them. This study seeks to better understand TEs cope with genomic defenses or reactivations using a fungal wheat pathogen.
Image credit: Irena Carpaccio
02/22/2023
Research Article
This study describes the creation of two mouse lines in which the ACE2, the protein Covid-19 binds to, chromosomal segment is replaced with the equivalent human DNA, showing qualitative and quantitative differences between ACE2 expression driven by the mouse and human promoters that are likely to impact disease progression in the two species.
Image credit: EMW
02/23/2023
Review
This review sought to better understand the biogenesis of extracellular vesicles in protozoan parasites as a means to inform therapeutic interventions, with a focus on the Endosomal Sorting Complex Required for Transport machinery. This review highlights the diversity in EV biogenesis in protozoa, as well as the related involvement of the ESCRT system in these unique organisms.
Image credit: Camacho et al
02/23/2023
Pearls
This review from Dr. Liliane Mukaremera aims to assess new insights into the unique attributes about the Cryptococcus cell wall in relation to the pathogenic lifestyle of these important pathogens
Image credit: Wikipedia/Nephron
02/13/2023
Research Article
This study identified the pivotal role of peritrophic matrix-driven intestinal homeostasis in dengue and Zika infection, unveiling a new physiological role of this barrier for arboviral establishment in the mosquito
Image credit: Talyuli et al
02/01/2023
Research Article
This study describes a single-cell screening assay that allows rapid high-throughput optimizing of a human antibody on mammalian cells.
Image credit: Yang et al
01/25/2023
Research Article
This study used a genome-wide screen to investigate the molecular determinants influencing P. aeruginosa survival in human plasma.
Image credit: Janet-Maitre
02/06/2023
Research Article
. This study sought to better understand the role of mutations that support AIV-infection in mammals after bird-to-human transmission, including the role of viral neuraminidase.
Image credit: Schleibner et al
01/26/2023
Research Article
This study seeks to characterize the existence and functional importance of RNA G-quadruplex in several host factors. RG4 is an RNA secondary structure, recently implicated in the regulation of SARS-CoV-2 and host factors.
Image credit: Tong et al
Brittany Seibert, C. Joaquín Cáceres, and colleagues
Qi-Yue Yang, Yong-Le Yang, and colleagues
Frideborg Bradley and colleagues
Jodie A. Schiffer & Stephanie V. Stumbur and colleagues
B. Karina Montero and colleagues
Hakimi et al.
Jansen et al.
Verburg et al.
Sheedlo et al.
Jafarzadeh et al.
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