Failure to Detect the Novel Retrovirus XMRV in Chronic Fatigue Syndrome

Otto Erlwein; Steve Kaye; Myra O. McClure; Jonathan Weber; Gillian Wills; David Collier; Simon Wessely; Anthony Cleare

doi:10.1371/journal.pone.0008519

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Open Access

Peer-reviewed

Research Article

Failure to Detect the Novel Retrovirus XMRV in Chronic Fatigue Syndrome

Otto Erlwein,

Affiliation Jefferiss Research Trust Laboratories, Section of Infectious Diseases, Wright-Fleming Institute, Faculty of Medicine, Imperial College London, St Mary's Campus, Norfolk Place, London, United Kingdom
⨯
Steve Kaye,

Affiliation Jefferiss Research Trust Laboratories, Section of Infectious Diseases, Wright-Fleming Institute, Faculty of Medicine, Imperial College London, St Mary's Campus, Norfolk Place, London, United Kingdom
⨯
Myra O. McClure ,

* E-mail: m.mcclure@imperial.ac.uk

Affiliation Jefferiss Research Trust Laboratories, Section of Infectious Diseases, Wright-Fleming Institute, Faculty of Medicine, Imperial College London, St Mary's Campus, Norfolk Place, London, United Kingdom
⨯
Jonathan Weber,

Affiliation Jefferiss Research Trust Laboratories, Section of Infectious Diseases, Wright-Fleming Institute, Faculty of Medicine, Imperial College London, St Mary's Campus, Norfolk Place, London, United Kingdom
⨯
Gillian Wills,

Affiliation Jefferiss Research Trust Laboratories, Section of Infectious Diseases, Wright-Fleming Institute, Faculty of Medicine, Imperial College London, St Mary's Campus, Norfolk Place, London, United Kingdom
⨯
David Collier,

Affiliation Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry (King's College London) De Crespigny Park, Denmark Hill, London, United Kingdom
⨯
Simon Wessely,

Affiliation Department of Psychological Medicine, Institute of Psychiatry, King's College London, Camberwell, London, United Kingdom
⨯
Anthony Cleare

Affiliation Department of Psychological Medicine, Institute of Psychiatry, King's College London, Camberwell, London, United Kingdom
⨯

Failure to Detect the Novel Retrovirus XMRV in Chronic Fatigue Syndrome

Otto Erlwein,
Steve Kaye,
Myra O. McClure,
Jonathan Weber,
Gillian Wills,
David Collier,
Simon Wessely,
Anthony Cleare

Published: January 6, 2010
https://doi.org/10.1371/journal.pone.0008519

Reader Comments (61)

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0 Responses

17 Nov 2012
00:10 GMT
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Media Coverage of This Article Posted by PLOS_ONE_Group on 17 Nov 2012 at 00:10 GMT
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19 Aug 2010
10:09 GMT
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Findings by Reno scientists confirmed by US government. Posted by peggy-sue on 19 Aug 2010 at 10:09 GMT
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14 Apr 2010
16:14 GMT
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Failure of methodology. Posted by peggy-sue on 14 Apr 2010 at 16:14 GMT
0 Responses

14 Apr 2010
10:59 GMT
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Challenge from the WPI Posted by peggy-sue on 14 Apr 2010 at 10:59 GMT
11 Responses

21 Jan 2010
02:08 GMT
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Authors Response Posted by Anthony_Cleare on 12 Jan 2010 at 19:55 GMT
11 Responses

20 Jan 2010
20:55 GMT
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Results uninterpretable Posted by DustyMiller on 06 Jan 2010 at 14:13 GMT
1 Response

20 Jan 2010
20:50 GMT
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Implicit Bias in the Patient Cohort Posted by TerryE on 10 Jan 2010 at 23:30 GMT
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20 Jan 2010
20:49 GMT
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Possible missing comments Posted by PLOS_ONE_Group on 20 Jan 2010 at 20:49 GMT
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11 Jan 2010
15:54 GMT
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Diagnostic Testing Posted by Balbuie on 11 Jan 2010 at 15:54 GMT
5 Responses

10 Jan 2010
22:34 GMT
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Thank you, Erlwein et al. Posted by Ed_D on 07 Jan 2010 at 21:15 GMT
0 Responses

10 Jan 2010
02:32 GMT
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Failure to Detect XMRV = Failure to Use Good Science Posted by APring on 10 Jan 2010 at 02:32 GMT
0 Responses

09 Jan 2010
21:20 GMT
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Verification of accuracy can be tested Posted by npatel on 09 Jan 2010 at 21:20 GMT
0 Responses

09 Jan 2010
17:54 GMT
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Lab Contamination Posted by Balbuie on 09 Jan 2010 at 17:54 GMT
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09 Jan 2010
17:16 GMT
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Inaccuracy in Discussion Posted by Balbuie on 09 Jan 2010 at 17:16 GMT
0 Responses

09 Jan 2010
15:54 GMT
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Missing data Posted by EMGoudsmit on 09 Jan 2010 at 15:54 GMT
0 Responses

08 Jan 2010
23:59 GMT
Most Recent

Different XMRV sequences targeted for amplification Posted by MDMS on 08 Jan 2010 at 23:59 GMT
0 Responses

08 Jan 2010
02:23 GMT
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Incomplete Posted by RubenDonis on 08 Jan 2010 at 02:23 GMT
0 Responses

07 Jan 2010
16:53 GMT
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Weak Methodology Posted by APring on 07 Jan 2010 at 16:53 GMT
0 Responses

07 Jan 2010
16:50 GMT
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Failure to detect Posted by Derision on 07 Jan 2010 at 16:50 GMT
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07 Jan 2010
15:24 GMT
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Patient Cohort Posted by Alice2010 on 07 Jan 2010 at 15:24 GMT
0 Responses

07 Jan 2010
15:03 GMT
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Why not a more substantial discussion on discrepant XMRV findings? Posted by JohnM on 07 Jan 2010 at 15:03 GMT
0 Responses

07 Jan 2010
14:16 GMT
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Official Statement from the Whittemore Peterson Institute Posted by Herbiv4 on 07 Jan 2010 at 14:16 GMT
1 Response

07 Jan 2010
14:13 GMT
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Completely different cohort studied. NOT a replication study Posted by Science-Based on 07 Jan 2010 at 04:55 GMT
0 Responses

07 Jan 2010
12:42 GMT
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Still waiting for a valid replication Posted by AndrewMillman on 07 Jan 2010 at 12:42 GMT
0 Responses

07 Jan 2010
05:03 GMT
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Posted by Science-Based on 07 Jan 2010 at 05:03 GMT
1 Response

07 Jan 2010
02:56 GMT
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Need for rigorous study and exacting protocols Posted by kelly1 on 07 Jan 2010 at 01:46 GMT
0 Responses

07 Jan 2010
01:16 GMT
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My previous comments were removed Posted by Drmartinwhite on 07 Jan 2010 at 01:16 GMT
0 Responses

07 Jan 2010
00:48 GMT
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Not a valid replication study Posted by moms on 07 Jan 2010 at 00:48 GMT
0 Responses

06 Jan 2010
18:38 GMT
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Reference is a prostate Cancer not CFS study Posted by tkindlon on 06 Jan 2010 at 18:38 GMT
0 Responses

06 Jan 2010
16:05 GMT
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Not very useful Posted by heinrichvs on 06 Jan 2010 at 16:05 GMT
0 Responses

06 Jan 2010
11:57 GMT
Most Recent

XMRV Negative Results Emphasize Need for Robust Replication Study Posted by Arabella on 06 Jan 2010 at 11:57 GMT

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