Characterization of Detergent-Insoluble Proteins in ALS Indicates a Causal Link between Nitrative Stress and Aggregation in Pathogenesis

Manuela Basso; Giuseppina Samengo; Giovanni Nardo; Tania Massignan; Giuseppina D'Alessandro; Silvia Tartari; Lavinia Cantoni; Marianna Marino; Cristina Cheroni; Silvia De Biasi; Maria Teresa Giordana; Michael J. Strong; Alvaro G. Estevez; Mario Salmona; Caterina Bendotti; Valentina Bonetto

doi:10.1371/journal.pone.0008130

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Peer-reviewed

Research Article

Characterization of Detergent-Insoluble Proteins in ALS Indicates a Causal Link between Nitrative Stress and Aggregation in Pathogenesis

Manuela Basso,

Current address: Burke Medical Research Institute, White Plains, New York, United States of America

Affiliations Dulbecco Telethon Institute, Milan, Italy, Department of Molecular Biochemistry and Pharmacology, “Mario Negri” Institute for Pharmacological Research, Milan, Italy
⨯
Giuseppina Samengo,

Affiliations Dulbecco Telethon Institute, Milan, Italy, Department of Molecular Biochemistry and Pharmacology, “Mario Negri” Institute for Pharmacological Research, Milan, Italy
⨯
Giovanni Nardo,

Affiliations Dulbecco Telethon Institute, Milan, Italy, Department of Molecular Biochemistry and Pharmacology, “Mario Negri” Institute for Pharmacological Research, Milan, Italy
⨯
Tania Massignan,

Affiliations Dulbecco Telethon Institute, Milan, Italy, Department of Molecular Biochemistry and Pharmacology, “Mario Negri” Institute for Pharmacological Research, Milan, Italy
⨯
Giuseppina D'Alessandro,

Affiliation Department of Molecular Biochemistry and Pharmacology, “Mario Negri” Institute for Pharmacological Research, Milan, Italy
⨯
Silvia Tartari,

Affiliation Department of Molecular Biochemistry and Pharmacology, “Mario Negri” Institute for Pharmacological Research, Milan, Italy
⨯
Lavinia Cantoni,

Affiliation Department of Molecular Biochemistry and Pharmacology, “Mario Negri” Institute for Pharmacological Research, Milan, Italy
⨯
Marianna Marino,

Affiliation Department of Neuroscience, “Mario Negri” Institute for Pharmacological Research, Milan, Italy
⨯
Cristina Cheroni,

Affiliation Department of Neuroscience, “Mario Negri” Institute for Pharmacological Research, Milan, Italy
⨯
Silvia De Biasi,

Affiliation Department of Biomolecular Sciences and Biotechnology, University of Milan, Milan, Italy
⨯
Maria Teresa Giordana,

Affiliation Department of Neuroscience, University of Turin, Turin, Italy
⨯
Michael J. Strong,

Affiliation Robarts Research Institute and Department of Clinical Neurological Sciences, University of Western Ontario, London, Ontario, Canada
⨯
Alvaro G. Estevez,

Affiliation Burke Medical Research Institute, White Plains, New York, United States of America
⨯
Mario Salmona,

Affiliation Department of Molecular Biochemistry and Pharmacology, “Mario Negri” Institute for Pharmacological Research, Milan, Italy
⨯
Caterina Bendotti,

Affiliation Department of Neuroscience, “Mario Negri” Institute for Pharmacological Research, Milan, Italy
⨯
[ ... ],
Valentina Bonetto

* E-mail: valentina.bonetto@marionegri.it

Affiliations Dulbecco Telethon Institute, Milan, Italy, Department of Molecular Biochemistry and Pharmacology, “Mario Negri” Institute for Pharmacological Research, Milan, Italy
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Characterization of Detergent-Insoluble Proteins in ALS Indicates a Causal Link between Nitrative Stress and Aggregation in Pathogenesis

Manuela Basso,
Giuseppina Samengo,
Giovanni Nardo,
Tania Massignan,
Giuseppina D'Alessandro,
Silvia Tartari,
Lavinia Cantoni,
Marianna Marino,
Cristina Cheroni,
Silvia De Biasi

Published: December 2, 2009
https://doi.org/10.1371/journal.pone.0008130

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