Selective and Irreversible Inhibitors of Mosquito Acetylcholinesterases for Controlling Malaria and Other Mosquito-Borne Diseases

Yuan-Ping Pang; Fredrik Ekström; Gregory A. Polsinelli; Yang Gao; Sandeep Rana; Duy H. Hua; Björn Andersson; Per Ola Andersson; Lei Peng; Sanjay K. Singh; Rajesh K. Mishra; Kun Yan Zhu; Ann M. Fallon; David W. Ragsdale; Stephen Brimijoin

doi:10.1371/journal.pone.0006851

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Open Access

Peer-reviewed

Research Article

Selective and Irreversible Inhibitors of Mosquito Acetylcholinesterases for Controlling Malaria and Other Mosquito-Borne Diseases

Yuan-Ping Pang ,

* E-mail: pang@mayo.edu (YPP); fredrik.ekstrom@foi.se (FE); brimijoi@mayo.edu (SB)

Affiliation Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Fredrik Ekström ,

* E-mail: pang@mayo.edu (YPP); fredrik.ekstrom@foi.se (FE); brimijoi@mayo.edu (SB)

Affiliation Swedish Defence Research Agency, CBRN Defence and Security, Umeå, Sweden
⨯
Gregory A. Polsinelli,

Affiliation Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Yang Gao,

Affiliation Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Sandeep Rana,

Affiliation Department of Chemistry, Kansas State University, Manhattan, Kansas, United States of America
⨯
Duy H. Hua,

Affiliation Department of Chemistry, Kansas State University, Manhattan, Kansas, United States of America
⨯
Björn Andersson,

Affiliation Swedish Defence Research Agency, CBRN Defence and Security, Umeå, Sweden
⨯
Per Ola Andersson,

Affiliation Swedish Defence Research Agency, CBRN Defence and Security, Umeå, Sweden
⨯
Lei Peng,

Affiliation Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Sanjay K. Singh,

Current address: Department of Chemistry, University of Louisville, Louisville, Kentucky, United States of America

Affiliation Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Rajesh K. Mishra,

Affiliation Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Kun Yan Zhu,

Affiliation Department of Entomology, Kansas State University, Manhattan, Kansas, United States of America
⨯
Ann M. Fallon,

Affiliation Department of Entomology, University of Minnesota, Saint Paul, Minnesota, United States of America
⨯
David W. Ragsdale,

Affiliation Department of Entomology, University of Minnesota, Saint Paul, Minnesota, United States of America
⨯
Stephen Brimijoin

* E-mail: pang@mayo.edu (YPP); fredrik.ekstrom@foi.se (FE); brimijoi@mayo.edu (SB)

Affiliation Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota, United States of America
⨯

Selective and Irreversible Inhibitors of Mosquito Acetylcholinesterases for Controlling Malaria and Other Mosquito-Borne Diseases

Yuan-Ping Pang,
Fredrik Ekström,
Gregory A. Polsinelli,
Yang Gao,
Sandeep Rana,
Duy H. Hua,
Björn Andersson,
Per Ola Andersson,
Lei Peng,
Sanjay K. Singh

Published: August 28, 2009
https://doi.org/10.1371/journal.pone.0006851

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