A Systems Biology Strategy Reveals Biological Pathways and Plasma Biomarker Candidates for Potentially Toxic Statin-Induced Changes in Muscle

• Reijo Laaksonen ,

  *To whom correspondence should be addressed. E-mail: reijo.laaksonen@helsinki.fi (RL); matej.oresic@vtt.fi (MO)

  Affiliation Research Unit, University Hospital of Tampere, Tampere, Finland

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• Mikko Katajamaa,

  Affiliation Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland

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• Hannu Päivä,

  Affiliation Department of Internal Medicine, University Hospital of Tampere, Tampere, Finland

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• Marko Sysi-Aho,

  Affiliation VTT Technical Research Centre of Finland, Espoo, Finland

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• Lilli Saarinen,

  Affiliation Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland

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• Päivi Junni,

  Affiliation Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland

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• Dieter Lütjohann,

  Affiliation Department of Clinical Pharmacology, University of Bonn, Bonn, Germany

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• Joél Smet,

  Affiliation Department of Pediatrics, Division of Pediatric Neurology and Metabolism, Ghent University Hospital, Ghent, Belgium

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• Rudy Van Coster,

  Affiliation Department of Pediatrics, Division of Pediatric Neurology and Metabolism, Ghent University Hospital, Ghent, Belgium

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• Tuulikki Seppänen-Laakso,

  Affiliation VTT Technical Research Centre of Finland, Espoo, Finland

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• Terho Lehtimäki,

  Affiliations Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, Tampere, Finland, Centre for Laboratory Medicine, University Hospital of Tampere, Tampere, Finland, Medical School, University of Tampere, Tampere, Finland

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• Juhani Soini,

  Affiliation Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland

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• Matej Orešič

  *To whom correspondence should be addressed. E-mail: reijo.laaksonen@helsinki.fi (RL); matej.oresic@vtt.fi (MO)

  Affiliation VTT Technical Research Centre of Finland, Espoo, Finland

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