Psychedelic N,N-Dimethyltryptamine and 5-Methoxy-N,N-Dimethyltryptamine Modulate Innate and Adaptive Inflammatory Responses through the Sigma-1 Receptor of Human Monocyte-Derived Dendritic Cells

Attila Szabo; Attila Kovacs; Ede Frecska; Eva Rajnavolgyi

doi:10.1371/journal.pone.0106533

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Peer-reviewed

Research Article

Psychedelic N,N-Dimethyltryptamine and 5-Methoxy-N,N-Dimethyltryptamine Modulate Innate and Adaptive Inflammatory Responses through the Sigma-1 Receptor of Human Monocyte-Derived Dendritic Cells

Attila Szabo ,

* E-mail: szattila@med.unideb.hu

Affiliations Department of Immunology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary, Research Centre for Molecular Medicine, University of Debrecen, Debrecen, Hungary
⨯
Attila Kovacs,

Affiliation Department of Psychiatry, Faculty of Medicine, University of Debrecen, Debrecen, Hungary
⨯
Ede Frecska ,

Contributed equally to this work with: Ede Frecska, Eva Rajnavolgyi

Affiliation Department of Psychiatry, Faculty of Medicine, University of Debrecen, Debrecen, Hungary
⨯
Eva Rajnavolgyi

Contributed equally to this work with: Ede Frecska, Eva Rajnavolgyi

Affiliations Department of Immunology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary, Research Centre for Molecular Medicine, University of Debrecen, Debrecen, Hungary
⨯

Psychedelic N,N-Dimethyltryptamine and 5-Methoxy-N,N-Dimethyltryptamine Modulate Innate and Adaptive Inflammatory Responses through the Sigma-1 Receptor of Human Monocyte-Derived Dendritic Cells

Attila Szabo,
Attila Kovacs,
Ede Frecska,
Eva Rajnavolgyi

Published: August 29, 2014
https://doi.org/10.1371/journal.pone.0106533

About the Authors

Attila Szabo

* E-mail: szattila@med.unideb.hu

Affiliations Department of Immunology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary, Research Centre for Molecular Medicine, University of Debrecen, Debrecen, Hungary

Attila Kovacs

Affiliation Department of Psychiatry, Faculty of Medicine, University of Debrecen, Debrecen, Hungary

Ede Frecska

Contributed equally to this work with: Ede Frecska, Eva Rajnavolgyi

Affiliation Department of Psychiatry, Faculty of Medicine, University of Debrecen, Debrecen, Hungary

Eva Rajnavolgyi

Contributed equally to this work with: Ede Frecska, Eva Rajnavolgyi

Affiliations Department of Immunology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary, Research Centre for Molecular Medicine, University of Debrecen, Debrecen, Hungary

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AS AK EF ER. Performed the experiments: AS AK EF. Analyzed the data: AS AK EF ER. Contributed reagents/materials/analysis tools: AK EF ER. Contributed to the writing of the manuscript: AS AK EF ER.

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Cytokines
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T cells
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Inflammation
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Cytokine therapy
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Small interfering RNA
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Secretion
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Central nervous system
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Dendritic cells
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