About the Authors
- R. Guy Reeves
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* E-mail: reeves@evolbio.mpg.de
Affiliation Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Plön, Germany
- Jarosław Bryk
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Current address: National Centre for Biotechnology Education, University of Reading, Earley Gate, Whiteknights Road, Reading, United Kingdom.
Affiliation Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Plön, Germany
- Philipp M. Altrock
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Current address: Dana-Farber Cancer Institute and Harvard School of Public Health, Boston, Massachusetts, United States of America.
Affiliation Department of Evolutionary Theory, Max Planck Institute for Evolutionary Biology, Plön, Germany
- Jai A. Denton
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Current address: Max Planck Group for Experimental Evolution, Max Planck Institute for Evolutionary Biology, Plön, Germany.
Affiliation Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Plön, Germany
- Floyd A. Reed
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Current address: Department of Biology, University of Hawaii at Mānoa, Honolulu, Hawaii, United States of America.
Affiliation Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Plön, Germany
Competing Interests
FAR and RGR are listed as inventors in the following patent application GB1223097.5 “Stable transformation of a population and a method of biocontainment using haploinsufficiency and underdominance principles.” This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.
Author Contributions
Conceived and designed the experiments: RGR FAR PMA JAD JB. Performed the experiments: RGR FAR PMA JAD JB. Analyzed the data: RGR FAR PMA JAD JB. Contributed reagents/materials/analysis tools: FAR. Wrote the paper: RGR FAR PMA JAD JB. Designed the population experiments: FAR RGR. Performed the population experiments: FAR RGR PMA JAD. Developed the spatial stability analysis: PMA FAR. Developed the allele specific expression assay: JB. Wrote the additional file 1 along with the other authors: JAD. Conceived the design of the underdominant approach and executed the construction of {Ud}: RGR. Participated in the in vivo validation of {Ud} construct, measured life history data and performed MLE data analysis: FAR.