About the Authors

Alan Winston

a.winston@imperial.ac.uk

Affiliations Section of Infectious Diseases, Division of Medicine, Imperial College London, St Mary's Hospital Campus, Norfolk Place, London, United Kingdom, Department of HIV and GU Medicine, Imperial College Healthcare NHS Trust, London, United Kingdom

Alejandro Arenas-Pinto

Affiliations Medical Research Council Clinical Trials Unit, London, United Kingdom, Centre for Sexual Health and HIV Research, University College London, London, United Kingdom

Wolfgang Stöhr

Affiliation Medical Research Council Clinical Trials Unit, London, United Kingdom

Martin Fisher

Affiliation Brighton and Sussex University Hospitals NHS Trust, Brighton, United Kingdom

Chloe M. Orkin

Affiliation Barts Health NHS Trust, Ambrose King Centre, Royal London Hospital, London, United Kingdom

Kazeem Aderogba

Affiliation East Sussex Healthcare Trust, Avenue House, Eastbourne, United Kingdom

Andrew De Burgh-Thomas

Affiliation Gloucestershire Care Services, Hope House, Gloucestershire Royal Hospital, Gloucester, United Kingdom

Nigel O'Farrell

Affiliation Pasteur Suite, Ealing Hospital, London, United Kingdom

Charles JN. Lacey

Affiliation Centre for Immunology and Infection, Hull York Medical School, University of York, York, United Kingdom

Clifford Leen

Affiliations Edinburgh Infectious Diseases, Edinburgh University Regional Infectious Diseases Unit, Western General Hospital, Edinburgh, United Kingdom, Edinburgh University, Edinburgh, United Kingdom

David Dunn

Affiliation Medical Research Council Clinical Trials Unit, London, United Kingdom

Nicholas I. Paton

Affiliations Medical Research Council Clinical Trials Unit, London, United Kingdom, National University of Singapore, Singapore

for the PIVOT Trial Team

The members of the PIVOT Trial Team are listed in the Acknowledgements section

Competing Interests

The authors have read the journal's policy and have the following conflicts: AW has received honoraria or research grants, or been a consultant or investigator, in clinical trials sponsored by Abbott, Boehringer Ingelheim, Bristol-Myers Squibb, Gilead Sciences, GlaxoSmithKline, Janssen Cilag, Roche, and Pfizer. All other authors have no conflict of interest. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: AW NP DD AP WS. Performed the experiments: AP WS. Analyzed the data: WS DD. Contributed reagents/materials/analysis tools: WS DD AP. Wrote the paper: AW AP WS DD NP MF CO KA ADT CJNL CL NO.