Amino Acid Substitutions in Cold-Adapted Proteins from Halorubrum lacusprofundi, an Extremely Halophilic Microbe from Antarctica

Shiladitya DasSarma; Melinda D. Capes; Ram Karan; Priya DasSarma

doi:10.1371/journal.pone.0058587

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Peer-reviewed

Research Article

Amino Acid Substitutions in Cold-Adapted Proteins from Halorubrum lacusprofundi, an Extremely Halophilic Microbe from Antarctica

Shiladitya DasSarma ,

* E-mail: sdassarma@som.umaryland.edu

Affiliation Department of Microbiology and Immunology, and Institute of Marine and Environmental Technology, University of Maryland, Baltimore, Maryland, United States of America
⨯
Melinda D. Capes,

Affiliation Department of Microbiology and Immunology, and Institute of Marine and Environmental Technology, University of Maryland, Baltimore, Maryland, United States of America
⨯
Ram Karan,

Affiliation Department of Microbiology and Immunology, and Institute of Marine and Environmental Technology, University of Maryland, Baltimore, Maryland, United States of America
⨯
Priya DasSarma

Affiliation Department of Microbiology and Immunology, and Institute of Marine and Environmental Technology, University of Maryland, Baltimore, Maryland, United States of America
⨯

Amino Acid Substitutions in Cold-Adapted Proteins from Halorubrum lacusprofundi, an Extremely Halophilic Microbe from Antarctica

Shiladitya DasSarma,
Melinda D. Capes,
Ram Karan,
Priya DasSarma

Published: March 11, 2013
https://doi.org/10.1371/journal.pone.0058587

About the Authors

Shiladitya DasSarma

* E-mail: sdassarma@som.umaryland.edu

Affiliation Department of Microbiology and Immunology, and Institute of Marine and Environmental Technology, University of Maryland, Baltimore, Maryland, United States of America

Melinda D. Capes

Affiliation Department of Microbiology and Immunology, and Institute of Marine and Environmental Technology, University of Maryland, Baltimore, Maryland, United States of America

Ram Karan

Affiliation Department of Microbiology and Immunology, and Institute of Marine and Environmental Technology, University of Maryland, Baltimore, Maryland, United States of America

Priya DasSarma

Affiliation Department of Microbiology and Immunology, and Institute of Marine and Environmental Technology, University of Maryland, Baltimore, Maryland, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SD. Performed the experiments: SD MDC RK PD. Analyzed the data: SD MDC RK PD. Contributed reagents/materials/analysis tools: SD MDC RK PD. Wrote the paper: SD MDC RK PD.

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Amino acid substitution
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Amino acid analysis
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Genome analysis
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Protein sequencing
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Protein structure comparison
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Genomics
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Sequence alignment
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Comparative genomics
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