About the Authors
- Anke M. Mulder
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* E-mail: mulder@nanoimagingservices.com (AMM); qinjianzhao@gmail.com (QZ)
Affiliation Department of Research & Development, NanoImaging Services, La Jolla, California, United States of America
- Bridget Carragher
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Affiliation Department of Research & Development, NanoImaging Services, La Jolla, California, United States of America
- Victoria Towne
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Affiliation Merck Manufacturing Division, Vaccine Manufacturing Science and Commercialization, West Point, Pennsylvania, United States of America
- Yuan Meng
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Affiliation Vaccine Analytical R&D, Merck Research Laboratories, West Point, Pennsylvania, United States of America
- Yang Wang
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Current address: Sino Biologicals, Inc., Beijing, China
Affiliation Vaccine Analytical R&D, Merck Research Laboratories, West Point, Pennsylvania, United States of America
- Lance Dieter
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Affiliation Vaccine Bioprocess R&D, Merck Research Laboratories, West Point, Pennsylvania, United States of America
- Clinton S. Potter
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Affiliation Department of Research & Development, NanoImaging Services, La Jolla, California, United States of America
- Michael W. Washabaugh
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Current address: MedImmune, Gaithersburg, Maryland, United States of America
Affiliation Vaccine Analytical R&D, Merck Research Laboratories, West Point, Pennsylvania, United States of America
- Robert D. Sitrin
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Current address: SitrinSolutions, LLC, Lafayette Hill, Pennsylvania, United States of America
Affiliation Merck Manufacturing Division, Vaccine Manufacturing Science and Commercialization, West Point, Pennsylvania, United States of America
- Qinjian Zhao
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* E-mail: mulder@nanoimagingservices.com (AMM); qinjianzhao@gmail.com (QZ)
Current address: School of Public Health, Xiamen University, Xiamen, Fujian, China
Affiliation Vaccine Analytical R&D, Merck Research Laboratories, West Point, Pennsylvania, United States of America
Competing Interests
AMM, BC, and CSP are employed at NanoImaging Services, Inc. VT, YM, YW, LD, MWW, RDS, and QZ are employed by Merck & Co. CryoTEM imaging and 3D reconstruction was performed by the Department of Operations at NanoImaging Services, Inc. (www.nanoimagingservices.com) as a service paid for by Merck & Co (www.merck.com). There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials, as detailed online in the guide for authors.
Author Contributions
Conceived and designed the experiments: QZ BC CP MW RS. Performed the experiments: LD QZ YW VT YM BC. Analyzed the data: AMM QZ BC. Wrote the paper: AMM QZ RS.