About the Authors

Laura Breda

Affiliation Department of Pediatrics, Division of Hematology-Oncology, Children's Blood and Cancer Foundation Laboratories, Weill Cornell Medical College, New York, New York, United States of America

Carla Casu

Affiliation Department of Pediatrics, Division of Hematology-Oncology, Children's Blood and Cancer Foundation Laboratories, Weill Cornell Medical College, New York, New York, United States of America

Sara Gardenghi

Affiliation Department of Pediatrics, Division of Hematology-Oncology, Children's Blood and Cancer Foundation Laboratories, Weill Cornell Medical College, New York, New York, United States of America

Nicoletta Bianchi

Affiliation Dipartimento di Biochimica e Biologia Molecolare, Universita' di Ferrara, Ferrara, Italy

Luca Cartegni

Affiliation Department of Molecular Pharmacology and Chemistry, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America

Mohandas Narla

Affiliation Red Cell Physiology Laboratory, New York Blood Center, New York, New York, United States of America

Karina Yazdanbakhsh

Affiliation Red Cell Physiology Laboratory, New York Blood Center, New York, New York, United States of America

Marco Musso

Affiliation Centro della Microcitemia e Anemie Congenite, Ospedali Galliera, Genova, Italy

Deepa Manwani

Affiliation Department of Pediatrics, Albert Einstein College of Medicine, Children's Hospital at Montefiore, Bronx, New York, United States of America

Jane Little

Affiliation Department of Medicine, Montefiore Medical Center, Bronx, New York, United States of America

Lawrence B. Gardner

Affiliation Department of Pharmacology, Langone Medical Center, New York University, New York, New York, United States of America

Dorothy A. Kleinert

Affiliation Department of Pediatrics, Division of Hematology-Oncology, Children's Blood and Cancer Foundation Laboratories, Weill Cornell Medical College, New York, New York, United States of America

Eugenia Prus

Affiliation Department of Hematology, Hadassah–Hebrew University Medical Center, Jerusalem, Israel

Eitan Fibach

Affiliation Department of Hematology, Hadassah–Hebrew University Medical Center, Jerusalem, Israel

Robert W. Grady

Affiliation Department of Pediatrics, Division of Hematology-Oncology, Children's Blood and Cancer Foundation Laboratories, Weill Cornell Medical College, New York, New York, United States of America

Patricia J. Giardina

Affiliation Department of Pediatrics, Division of Hematology-Oncology, Children's Blood and Cancer Foundation Laboratories, Weill Cornell Medical College, New York, New York, United States of America

Roberto Gambari

Affiliation Dipartimento di Biochimica e Biologia Molecolare, Universita' di Ferrara, Ferrara, Italy

Stefano Rivella

str2010@med.cornell.edu

Affiliations Department of Pediatrics, Division of Hematology-Oncology, Children's Blood and Cancer Foundation Laboratories, Weill Cornell Medical College, New York, New York, United States of America, Department of Cell and Developmental Biology, Weill Cornell Medical College, New York, New York, United States of America

Competing Interests

S. Rivella is a consultant for Novartis. In addition, he is a co-inventor for the patents US8058061 B2 C12N 20111115 and US7541179 B2 C12N 20090602. The consulting work and intellectual property of S. Rivella did not affect in any way the design, conduct, or reporting of this research. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: LB SR SG MN EF LC LBG. Performed the experiments: LB CC SG MM RWG EP NB. Analyzed the data: LB SR RWG EP EF NB. Contributed reagents/materials/analysis tools: RG NB EF EP LC KY MM DM JL LBG DAK PJG RWG. Wrote the paper: LB SR.