About the Authors

David R. Strayer

david.strayer@hemispherx.net (DRS); bill.mitchell@vanderbilt.edu (WMM)

Affiliation Hemispherx Biopharma, Inc., Philadelphia, Pennsylvania, United States of America

William A. Carter

Affiliation Hemispherx Biopharma, Inc., Philadelphia, Pennsylvania, United States of America

Bruce C. Stouch

Affiliation BCS Consulting, Philadelphia, Pennsylvania, United States of America

Staci R. Stevens

Affiliation University of the Pacific, Stockton, California, United States of America

Lucinda Bateman

Affiliation Fatigue Consultation Clinic, Salt Lake City, Utah, United States of America

Paul J. Cimoch

Affiliation Center for Special Immunology, Fountain Valley, California, United States of America

Charles W. Lapp

Affiliation Hunter-Hopkins Center, Charlotte, North Carolina, United States of America

Daniel L. Peterson

Affiliation Sierra Internal Medicine Associates, Incline Village, Nevada, United States of America

the Chronic Fatigue Syndrome AMP-516 Study Group

For a list of the members of Chronic Fatigue Syndrome AMP-516 Clinical Study Group please see Table S2.

William M. Mitchell

david.strayer@hemispherx.net (DRS); bill.mitchell@vanderbilt.edu (WMM)

Affiliation Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

Competing Interests

LB, BCS, RNP and CWL have consulted for, or received lecture fees from Hemispherx Biopharma. All clinical investigators received support budgets from Hemispherx Biopharma for the conduct of the clinical trial to support the New Drug Application (NDA) of Ampligen (rintatolimod) for the treatment of CFS. DRS, the Medical Director, and WAC, the CEO, of Hemispherx, both own stock and options in Hemispherx Biopharma. WAC and WMM are members of the Board of Directors for Hemispherx Biopharma and own stock and options. SRS has received non-rintatolimod related grant support from the CFIDS Association of America. A patent for the use of rintatolimod for CFS was granted to Hemispherx during the conduct of this study (patent number is 6,130,206 and the date is October 10, 2000). Hemispherx has several patents pending for CFS. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: DRS WAC. Performed the experiments: SRS LB PJC CWL DLP. Analyzed the data: DRS WAC BCS WMM. Contributed reagents/materials/analysis tools: BCS SRS. Wrote the paper: DRS WMM.