About the Authors

Ana L. Alessandri

Affiliation Medical Research Council Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, Scotland, United Kingdom

Rodger Duffin

rodger.duffin@ed.ac.uk

Affiliation Medical Research Council Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, Scotland, United Kingdom

Andrew E. Leitch

Affiliation Medical Research Council Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, Scotland, United Kingdom

Christopher D. Lucas

Affiliation Medical Research Council Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, Scotland, United Kingdom

Tara A. Sheldrake

Affiliation Medical Research Council Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, Scotland, United Kingdom

David A. Dorward

Affiliation Medical Research Council Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, Scotland, United Kingdom

Nik Hirani

Affiliation Medical Research Council Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, Scotland, United Kingdom

Vanessa Pinho

Affiliation Imunofarmacologia, Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil

Lirlândia Pires de Sousa

Affiliation Imunofarmacologia, Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil

Mauro M. Teixeira

Affiliation Imunofarmacologia, Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil

John F. Lyons

Affiliation Astex Therapeutics, Cambridge, England, United Kingdom

Christopher Haslett

Affiliation Medical Research Council Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, Scotland, United Kingdom

Adriano G. Rossi

Affiliation Medical Research Council Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, Scotland, United Kingdom

Competing Interests

The authors have read the journal's policy and have the following conflict: The authors have a non-financial academic link with Astex Therapeutics who kindly gifted them with the cyclin-dependent kinase inhibitor, AT7519. This compound is also commercially available (Selleck). This does not alter the authors' adherence to all PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: ALA RD AGR. Performed the experiments: ALA RD AEL CDL TAS DAD. Analyzed the data: ALA RD CDL. Contributed reagents/materials/analysis tools: JFL. Wrote the paper: ALA RD AEL CDL CH AGR. Intellectual input into study design and manuscript editing: NH VP LPdS MMT.