About the Authors

Shuichi Segawa

Affiliation Frontier Laboratories of Value Creation, Sapporo Breweries Ltd., Yaizu, Japan

Mikihiro Fujiya

fjym@asahikawa-med.ac.jp

Affiliation Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, Asahikawa, Japan

Hiroaki Konishi

Affiliation Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, Asahikawa, Japan

Nobuhiro Ueno

Affiliation Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, Asahikawa, Japan

Naoyuki Kobayashi

Affiliation Frontier Laboratories of Value Creation, Sapporo Breweries Ltd., Yaizu, Japan

Tatsuro Shigyo

Affiliation Frontier Laboratories of Value Creation, Sapporo Breweries Ltd., Yaizu, Japan

Yutaka Kohgo

Affiliation Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, Asahikawa, Japan

Competing Interests

S. Segawa, N. Kobayashi and T. Shigyo are employed by Sapporo Breweries Ltd. Sapporo Breweries Ltd and Asahikawa Medical University have a patent application on this study. The patent name is Intestinal Tract Protective Agent. The patent number is PCT/JP2011/057689. There is no product in development and marketed product related to this research. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: SS MF YK. Performed the experiments: SS MF HK NU NK. Analyzed the data: SS MF. Contributed reagents/materials/analysis tools: TS. Wrote the paper: SS MF TS YK.