About the Authors

Dongying Wu

Affiliation Department of Evolution and Ecology, Department of Medical Microbiology and Immunology, University of California Davis Genome Center, University of California Davis, Davis, California, United States of America

Martin Wu

Affiliations Department of Evolution and Ecology, Department of Medical Microbiology and Immunology, University of California Davis Genome Center, University of California Davis, Davis, California, United States of America, University of Virginia, Charlottesville, Virginia, United States of America

Aaron Halpern

Affiliations The J. Craig Venter Institute, Rockville, Maryland, United States of America, The J. Craig Venter Institute, La Jolla, California, United States of America

Douglas B. Rusch

Affiliations The J. Craig Venter Institute, Rockville, Maryland, United States of America, The J. Craig Venter Institute, La Jolla, California, United States of America

Shibu Yooseph

Affiliations The J. Craig Venter Institute, Rockville, Maryland, United States of America, The J. Craig Venter Institute, La Jolla, California, United States of America

Marvin Frazier

Affiliations The J. Craig Venter Institute, Rockville, Maryland, United States of America, The J. Craig Venter Institute, La Jolla, California, United States of America

J. Craig Venter

Affiliations The J. Craig Venter Institute, Rockville, Maryland, United States of America, The J. Craig Venter Institute, La Jolla, California, United States of America

Jonathan A. Eisen

jaeisen@ucdavis.edu

Affiliation Department of Evolution and Ecology, Department of Medical Microbiology and Immunology, University of California Davis Genome Center, University of California Davis, Davis, California, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DW JAE. Performed the experiments: JAE DW MW AH DBR SY MF JCV. Analyzed the data: JAE DW MW AH DBR SY. Contributed reagents/materials/analysis tools: JCV. Wrote the paper: JAE DW. Ideas and discussion: MF JCV. Built microbial genome database: MW. Analyzed sequences linked to RecA and RpoB clusters: DBR. Analysis of distributions of sequences in GOS data: AH.