Adenosine Prevents TNFα-Induced Decrease in Endothelial Mitochondrial Mass via Activation of eNOS-PGC-1α Regulatory Axis

Theodore J. Kalogeris; Christopher Baines; Ronald J. Korthuis

doi:10.1371/journal.pone.0098459

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Open Access

Peer-reviewed

Research Article

Adenosine Prevents TNFα-Induced Decrease in Endothelial Mitochondrial Mass via Activation of eNOS-PGC-1α Regulatory Axis

Theodore J. Kalogeris ,

* E-mail: kalogerist@health.missouri.edu

Affiliation Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, Missouri, United States of America
⨯
Christopher Baines,

Affiliations Department of Biomedical Sciences, University of Missouri, Columbia, Missouri, United States of America, Dalton Cardiovascular Research Center, University of Missouri, Columbia, Missouri, United States of America
⨯
Ronald J. Korthuis

Affiliations Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, Missouri, United States of America, Dalton Cardiovascular Research Center, University of Missouri, Columbia, Missouri, United States of America
⨯

Adenosine Prevents TNFα-Induced Decrease in Endothelial Mitochondrial Mass via Activation of eNOS-PGC-1α Regulatory Axis

Theodore J. Kalogeris,
Christopher Baines,
Ronald J. Korthuis

Published: June 10, 2014
https://doi.org/10.1371/journal.pone.0098459

About the Authors

Theodore J. Kalogeris

* E-mail: kalogerist@health.missouri.edu

Affiliation Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, Missouri, United States of America

Christopher Baines

Affiliations Department of Biomedical Sciences, University of Missouri, Columbia, Missouri, United States of America, Dalton Cardiovascular Research Center, University of Missouri, Columbia, Missouri, United States of America

Ronald J. Korthuis

Affiliations Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, Missouri, United States of America, Dalton Cardiovascular Research Center, University of Missouri, Columbia, Missouri, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: TK CB RK. Performed the experiments: TK. Analyzed the data: TK. Contributed reagents/materials/analysis tools: TK CB RK. Wrote the paper: TK.

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Mitochondria
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Adenosine
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Apoptosis
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Biosynthesis
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Nitric oxide
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Endothelial cells
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Small interfering RNA
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Transfection
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