About the Authors

Lars Herfindal

lars.herfindal@biomed.uib.no

Affiliations Department of Biomedicine, University of Bergen, Bergen, Norway, Translational Signaling Group, Haukeland University Hospital, Bergen, Norway

Camilla Krakstad

Current address: Department of Clinical Science, University of Bergen, Bergen, Norway

Affiliation Department of Biomedicine, University of Bergen, Bergen, Norway

Lene Myhren

Affiliation Department of Biomedicine, University of Bergen, Bergen, Norway

Hanne Hagland

Affiliation Department of Biomedicine, University of Bergen, Bergen, Norway

Reidun Kopperud

Affiliation Department of Biomedicine, University of Bergen, Bergen, Norway

Knut Teigen

Affiliation Department of Biomedicine, University of Bergen, Bergen, Norway

Frank Schwede

Affiliation BIOLOG Life Science Institute, Bremen, Germany

Rune Kleppe

Affiliation Department of Biomedicine, University of Bergen, Bergen, Norway

Stein Ove Døskeland

Affiliation Department of Biomedicine, University of Bergen, Bergen, Norway

Competing Interests

The authors have read the journal's policy and have the following conflict: Dr. Frank Schwede is employed by the BIOLOG Life Science Institute that sells the cyclic nucleotide analogs that were used in this study. All other authors have declared that no competing interests exist. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: LH CK LM SOD. Performed the experiments: LH CK LM HH KT R. Kopperud. Analyzed the data: LH CK LM KT FS R. Kleppe R. Kopperud SOD. Contributed reagents/materials/analysis tools: FS. Wrote the paper: LH CK LM R. Kleppe FS SOD.