About the Authors
- Yuk-Sang Chan
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Contributed equally to this work with: Yuk-Sang Chan, Ryo Takeuchi, Jordan Jarjour, David S. Huen
Affiliation Department of Genetics, University of Cambridge, Cambridge, Cambridgeshire, United Kingdom
- Ryo Takeuchi
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Contributed equally to this work with: Yuk-Sang Chan, Ryo Takeuchi, Jordan Jarjour, David S. Huen
Affiliations Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Northwest Genome Engineering Consortium, Seattle, Washington, United States of America
- Jordan Jarjour
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Contributed equally to this work with: Yuk-Sang Chan, Ryo Takeuchi, Jordan Jarjour, David S. Huen
Affiliation Pregenen Inc., Seattle, Washington, United States of America
- David S. Huen
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Contributed equally to this work with: Yuk-Sang Chan, Ryo Takeuchi, Jordan Jarjour, David S. Huen
* E-mail: david.s.huen@gmail.com
Current address: Department of Applied Sciences, University of Wolverhampton, Wolverhampton, United Kingdom
Affiliation Department of Genetics, University of Cambridge, Cambridge, Cambridgeshire, United Kingdom
- Barry L. Stoddard
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Affiliations Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Northwest Genome Engineering Consortium, Seattle, Washington, United States of America
- Steven Russell
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Affiliations Department of Genetics, University of Cambridge, Cambridge, Cambridgeshire, United Kingdom, Cambridge Systems Biology Centre, Cambridge, Cambridgeshire, United Kingdom
Competing Interests
The authors have read the journal's policy and have the following potential conflicts: BLS is a founder, and JJ an employee and shareholder, of a biotechnology startup company (Pregenen Inc) that manufactures homing endonuclease variants of I-OnuI as described in this manuscript. Neither individual nor that company have any commercial stake or interest in the constructs described in this manuscript. The authors do not have patents on the material within the paper. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.
Author Contributions
Conceived and designed the experiments: YC RT JJ DSH BLS SR. Performed the experiments: YC RT JJ DSH. Analyzed the data: YC RT JJ DSH BLS SR. Contributed reagents/materials/analysis tools: YC RT JJ DSH. Wrote the paper: RT JJ DSH BLS SR.