About the Authors

Giorgio Pistis

Affiliation Division of Genetics and Cell Biology, San Raffaele Research Institute and Vita Salute University, Milano, Italy

Shawntel U. Okonkwo

Affiliation Cardiovascular Research Institute, University of California San Francisco, San Francisco, California, United States of America

Michela Traglia

Affiliation Division of Genetics and Cell Biology, San Raffaele Research Institute and Vita Salute University, Milano, Italy

Cinzia Sala

Affiliation Division of Genetics and Cell Biology, San Raffaele Research Institute and Vita Salute University, Milano, Italy

So-Youn Shin

Affiliation Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom

Corrado Masciullo

Affiliation Division of Genetics and Cell Biology, San Raffaele Research Institute and Vita Salute University, Milano, Italy

Iwan Buetti

Affiliation Division of Genetics and Cell Biology, San Raffaele Research Institute and Vita Salute University, Milano, Italy

Roberto Massacane

Affiliation Novi Ligure Hospital, Novi Ligure (Al), Italy

Massimo Mangino

Affiliation Department of Twin Research & Genetic Epidemiology, King's College London, London, United Kingdom

Swee-Lay Thein

Affiliation Department of Molecular Hematology, King’s College London, London, United Kingdom

Timothy D. Spector

Affiliation Department of Twin Research & Genetic Epidemiology, King's College London, London, United Kingdom

Santhi Ganesh

Membership of the CHARGE Consortium Hematology Working Group is provided in the Acknowledgments.

Affiliation Division of Cardiovascular Medicine, University of Michigan Health System, Ann Arbor, Michigan, United States of America

Nicola Pirastu

Affiliation Medical Genetics, Department of Reproductive Sciences and Development, University of Trieste, Trieste, Italy

Paolo Gasparini

Affiliations Medical Genetics, Department of Reproductive Sciences and Development, University of Trieste, Trieste, Italy, Medical Genetics, Department of Laboratory Medicine, Institute for Maternal and Child Health IRCCS-Burlo Garofolo, Trieste, Italy

Nicole Soranzo

Affiliations Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom, Department of Twin Research & Genetic Epidemiology, King's College London, London, United Kingdom

Clara Camaschella

Affiliation Division of Genetics and Cell Biology, San Raffaele Research Institute and Vita Salute University, Milano, Italy

Daniel Hart

Affiliations Cardiovascular Research Institute, University of California San Francisco, San Francisco, California, United States of America, Howard Hughes Medical Institute, Program in Gene Function and Expression and Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

Michael R. Green

Affiliation Howard Hughes Medical Institute, Program in Gene Function and Expression and Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

Daniela Toniolo

daniela.toniolo@hsr.it

Affiliations Division of Genetics and Cell Biology, San Raffaele Research Institute and Vita Salute University, Milano, Italy, Institute of Molecular Genetics-CNR, Pavia, Italy

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DT DH MG CC. Performed the experiments: GP DH SUO. Analyzed the data: GP MT. Wrote the paper: DT CC. Provided the informatics tools for data collection and analysis: CS CM IB. Organized the INGI-VB data collection: CS RM CC DT. Provided the data on their replica populations: S-YS MM S-LT TDS SG NP PG. Provided the replica populations: NS, CHARGE Consortium.