About the Authors
- Abdu Adem
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Affiliation Departments of Pharmacology, Faculty of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates
- Mahmoud Al Haj
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Affiliations Departments of Pharmacology, Faculty of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates, Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden
- Sheela Benedict
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Affiliation Internal Medicine, Faculty of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates
- Javed Yasin
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Affiliation Internal Medicine, Faculty of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates
- Nicolas Nagelkerke
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Affiliation Community Medicine, Faculty of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates
- Fred Nyberg
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Affiliation Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden
- Tim G. Yandle
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Affiliation Department of Medicine, University of Otago - Christchurch, Christchurch Hospital, Christchurch, New Zealand
- Chris M. Frampton
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Affiliation Department of Medicine, University of Otago - Christchurch, Christchurch Hospital, Christchurch, New Zealand
- Lynley K. Lewis
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Affiliation Department of Medicine, University of Otago - Christchurch, Christchurch Hospital, Christchurch, New Zealand
- M. Gary Nicholls
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Affiliation Department of Medicine, University of Otago - Christchurch, Christchurch Hospital, Christchurch, New Zealand
- Elsadig Kazzam
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* E-mail: kazzam@uaeu.ac.ae
Affiliation Internal Medicine, Faculty of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates
Competing Interests
Merck (United States of America) provided the gift of losartan for this study. There are no further patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide to authors.
Author Contributions
Contributed significantly, read and approved the manuscript: AA MH SB JY NN FN TY CF LKL MGN EK. Conceived and designed the experiments: TY MGN AA EK MH. Performed the experiments: TY LKL JY SB. Analyzed the data: CF NN TY LKL. Contributed reagents/materials/analysis tools: AA MH EK MGN TY. Wrote the paper: MH AA MGN EK TY.