About the Authors

Jing-Fei Jiang

Contributed equally to this work with: Jing-Fei Jiang, Yu-Gang Wang, Jun Hu

Affiliation Protein Science Laboratory of the Ministry of Education, Laboratory of Molecular Pharmacology and Pharmaceutical Sciences, School of Life Sciences and School of Medicine, Tsinghua University, Beijing, China

Yu-Gang Wang

Contributed equally to this work with: Jing-Fei Jiang, Yu-Gang Wang, Jun Hu

Affiliation Protein Science Laboratory of the Ministry of Education, Laboratory of Molecular Pharmacology and Pharmaceutical Sciences, School of Life Sciences and School of Medicine, Tsinghua University, Beijing, China

Jun Hu

Contributed equally to this work with: Jing-Fei Jiang, Yu-Gang Wang, Jun Hu

Affiliation Protein Science Laboratory of the Ministry of Education, Laboratory of Molecular Pharmacology and Pharmaceutical Sciences, School of Life Sciences and School of Medicine, Tsinghua University, Beijing, China

Fan Lei

Affiliation Protein Science Laboratory of the Ministry of Education, Laboratory of Molecular Pharmacology and Pharmaceutical Sciences, School of Life Sciences and School of Medicine, Tsinghua University, Beijing, China

Michael M. Kheir

Affiliation Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Xin-Pei Wang

Affiliation Protein Science Laboratory of the Ministry of Education, Laboratory of Molecular Pharmacology and Pharmaceutical Sciences, School of Life Sciences and School of Medicine, Tsinghua University, Beijing, China

Yu-Shuang Chai

Affiliation Protein Science Laboratory of the Ministry of Education, Laboratory of Molecular Pharmacology and Pharmaceutical Sciences, School of Life Sciences and School of Medicine, Tsinghua University, Beijing, China

Zhi-Yi Yuan

Affiliation Protein Science Laboratory of the Ministry of Education, Laboratory of Molecular Pharmacology and Pharmaceutical Sciences, School of Life Sciences and School of Medicine, Tsinghua University, Beijing, China

Xi Lu

Affiliation Protein Science Laboratory of the Ministry of Education, Laboratory of Molecular Pharmacology and Pharmaceutical Sciences, School of Life Sciences and School of Medicine, Tsinghua University, Beijing, China

Dong-Ming Xing

Affiliation Protein Science Laboratory of the Ministry of Education, Laboratory of Molecular Pharmacology and Pharmaceutical Sciences, School of Life Sciences and School of Medicine, Tsinghua University, Beijing, China

Feng Du

Affiliation Department of Mathematics, Tulane University, New Orleans, Louisiana, United States of America

Li-Jun Du

lijundu@tsinghua.edu.cn

Affiliation Protein Science Laboratory of the Ministry of Education, Laboratory of Molecular Pharmacology and Pharmaceutical Sciences, School of Life Sciences and School of Medicine, Tsinghua University, Beijing, China

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Interpreted results of experiments: YSC ZYY XL. Edited and revised the manuscript: JFJ DMX LJD. Conceived and designed the experiments: JFJ YGW MMK LJD. Performed the experiments: JFJ YGW JH FL XPW LJD. Analyzed the data: LJD JFJ JH FD. Wrote the paper: LJD JFJ.