About the Authors

Hang Wang

Contributed equally to this work with: Hang Wang, Yi-Lin Chan

Affiliation Department of Food Science and Center of Excellence for Marine Bioenvironment and Biotechnology, National Taiwan Ocean University, Keelung, Taiwan

Yi-Lin Chan

Contributed equally to this work with: Hang Wang, Yi-Lin Chan

Affiliation Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan

Tsung-Lin Li

Affiliation Genomics Research Center, Academia Sinica, Taipei, Taiwan

Brent A. Bauer

Affiliation Division of General Internal Medicine, Mayo Clinic, Rochester, Minnesota, United States of America

Simon Hsia

Affiliation Institute of Biomedical Nutrition, Hung Kuang University, Taichung, Taiwan

Cheng-Hsu Wang

Affiliation Division of Hemato-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Keelung, and College of Medicine, Chang Gung University, Kaohsiung, Taiwan

Jen-Seng Huang

Affiliation Division of Hemato-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Keelung, and College of Medicine, Chang Gung University, Kaohsiung, Taiwan

Hung-Ming Wang

Affiliation Division of Hemato-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Kweishan, and College of Medicine, Chang Gung University, Kaohsiung, Taiwan

Kun-Yun Yeh

Affiliation Division of Hemato-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Keelung, and College of Medicine, Chang Gung University, Kaohsiung, Taiwan

Tse-Hung Huang

Affiliation Department of Traditional Chinese Medicine, Chang Gung Memorial Hospital, Kweishan, and Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Kaohsiung, Taiwan

Gwo-Jang Wu

Affiliation Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan

Chang-Jer Wu

wuchangjer@yahoo.com.tw

Affiliation Department of Food Science and Center of Excellence for Marine Bioenvironment and Biotechnology, National Taiwan Ocean University, Keelung, Taiwan

Competing Interests

The authors received experimental materials from a commercial source: “Do Well Laboratories, Inc., and Ethan Nutraceutical Limited Taiwan branch”, but this does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: HW YLC CJW BAB SH. Performed the experiments: HW. Analyzed the data: HW YLC. Contributed reagents/materials/analysis tools: CHW JSH HMW KYY THH GJW. Wrote the paper: HW YLC TLL CJW.