Advertisement
Table of Contents

February 2025

Cover
Issue Image

Knee osteoarthritis (OA) is a leading cause of pain worldwide. Although exercise can improve symptoms, joint replacement surgery is often used to treat OA. In this study, Belinda J Lawford and colleagues analyzed whether the use of X-ray imaging during diagnosis influences how OA is managed. In this randomized controlled trial, participants were asked to imagine that they went to a general practitioner with a painful knee. They then received an knee OA diagnosis either based on clinical symptoms or based on X-ray images. The use of X-rays during diagnosis increased the belief of participants that they needed joint replacement surgery. This study therefore suggests that the method of diagnosis could impact OA management practices.

Image Credit: Tung Lam, pixabay

Perspectives

Improving monitoring of sexual, reproductive health, and rights globally

Sacha St-Onge Ahmad, Zulfiqar A. Bhutta

PLOS Medicine: published February 6, 2025 | https://doi.org/10.1371/journal.pmed.1004525

Related Articles

  1. Comparative analysis of 2 approaches to monitor countries’ progress towards full and equal access to sexual and reproductive health care, information, and education in 75 countries: An observational validation study

Protecting mother and baby: Learnings from an Ebola vaccination campaign on the evolving landscape of vaccines and pregnancy

Rebecca F. Grais, Kathleen M. Neuzil, Helen Rees, Cristiana M. Toscano

PLOS Medicine: published February 11, 2025 | https://doi.org/10.1371/journal.pmed.1004530

Related Articles

  1. Contraception use and pregnancy in women receiving a 2-dose Ebola vaccine in Rwanda: A retrospective analysis of UMURINZI vaccination campaign data

Charting a novel path towards Ebola virus disease preparedness: Considerations for preventive vaccination

Donovan Guttieres, Charlot Diepvens, Rebecca F. Grais, Jackline Kiarie, Nico Vandaele, Catherine Decouttere

PLOS Medicine: published February 24, 2025 | https://doi.org/10.1371/journal.pmed.1004543

Detrimental infant and maternal outcomes of undiagnosed asymptomatic malaria in pregnancy

James G. Beeson, Daniel Herbert Opi

PLOS Medicine: published February 24, 2025 | https://doi.org/10.1371/journal.pmed.1004528

Research Articles

The effect of prenatal balanced energy and protein supplementation on gestational weight gain: An individual participant data meta-analysis in low- and middle-income countries

Dongqing Wang, Uttara Partap, Enju Liu, Janaína Calu Costa, Ilana R. Cliffer, Molin Wang, Sudeer Kumar Nookala, Vishak Subramoney, Brittany Briggs, Imran Ahmed, Alemayehu Argaw, Shabina Ariff, Nita Bhandari, Ranadip Chowdhury, Daniel Erchick, Armando García-Guerra, Masoumah Ghaffarpour, Giles Hanley-Cook, Lieven Huybregts, Fyezah Jehan, Fatemeh Kaseb, Nancy F. Krebs, Carl Lachat, Tsering Pema Lama, Dharma S. Manandhar, Elizabeth M. McClure, Sophie E. Moore, Ameer Muhammad, Lynnette M. Neufeld, Andrew M. Prentice, Amado D. Quezada-Sánchez, Dominique Roberfroid, Naomi M. Saville, Yasir Shafiq, Bhim P. Shrestha, Bakary Sonko, Sajid Soofi, Sunita Taneja, James M. Tielsch, Laéticia Céline Toe, Naser Valaei, Wafaie W. Fawzi

PLOS Medicine: published February 3, 2025 | https://doi.org/10.1371/journal.pmed.1004523

Impact evaluation of a digital health platform empowering Kenyan women across the pregnancy-postpartum care continuum: A cluster randomized controlled trial

Rajet Vatsa, Wei Chang, Sharon Akinyi, Sarah Little, Catherine Gakii, John Mungai, Cynthia Kahumbura, Anneka Wickramanayake, Sathyanath Rajasekharan, Jessica Cohen, Margaret McConnell

PLOS Medicine: published February 3, 2025 | https://doi.org/10.1371/journal.pmed.1004527

Risk of placenta previa in assisted reproductive technology: A Nordic population study with sibling analyses

Eirik Landsverk, Kjersti Westvik-Johari, Ulla-Britt Wennerholm, Christina Bergh, Frederik Kyhl, Anne Lærke Spangmose, Ditte Vassard, Anja Pinborg, Kristiina Rönö, Mika Gissler, Sindre Hoff Petersen, Signe Opdahl

PLOS Medicine: published February 3, 2025 | https://doi.org/10.1371/journal.pmed.1004536

Effects of X-ray–based diagnosis and explanation of knee osteoarthritis on patient beliefs about osteoarthritis management: A randomised clinical trial

Belinda J. Lawford, Kim L. Bennell, Dan Ewald, Peixuan Li, Anurika De Silva, Jesse Pardo, Barbara Capewell, Michelle Hall, Travis Haber, Thorlene Egerton, Stephanie Filbay, Fiona Dobson, Rana S. Hinman

PLOS Medicine: published February 4, 2025 | https://doi.org/10.1371/journal.pmed.1004537

Consecutive prediction of adverse maternal outcomes of preeclampsia, using the PIERS-ML and fullPIERS models: A multicountry prospective observational study

Guiyou Yang, Tünde Montgomery-Csobán, Wessel Ganzevoort, Sanne J. Gordijn, Kimberley Kavanagh, Paul Murray, Laura A. Magee, Henk Groen, Peter von Dadelszen

PLOS Medicine: published February 4, 2025 | https://doi.org/10.1371/journal.pmed.1004509

Accuracy and clinical effectiveness of risk prediction tools for pressure injury occurrence: An umbrella review

Bethany Hillier, Katie Scandrett, April Coombe, Tina Hernandez-Boussard, Ewout Steyerberg, Yemisi Takwoingi, Vladica M. Veličković, Jacqueline Dinnes

PLOS Medicine: published February 6, 2025 | https://doi.org/10.1371/journal.pmed.1004518

Potential public health impacts of gonorrhea vaccination programmes under declining incidences: A modeling study

Lin Geng, Lilith K. Whittles, Borame L. Dickens, Martin T. W. Chio, Yihao Chen, Rayner Kay Jin Tan, Azra Ghani, Jue Tao Lim

PLOS Medicine: published February 7, 2025 | https://doi.org/10.1371/journal.pmed.1004521

Contraception use and pregnancy in women receiving a 2-dose Ebola vaccine in Rwanda: A retrospective analysis of UMURINZI vaccination campaign data

Rosine Ingabire, Julien Nyombayire, Amelia Mazzei, Jean-Baptiste Mazarati, Jozef Noben, Michael Katwere, Rachel Parker, Sabin Nsanzimana, Kristin M. Wall, Tyronza Sharkey, Felix Sayinzoga, Amanda Tichacek, Niina Hammoud, Ellen Martinson, Ben Magod, Susan Allen, Etienne Karita

PLOS Medicine: published February 11, 2025 | https://doi.org/10.1371/journal.pmed.1004508

Related Articles

  1. Protecting mother and baby: Learnings from an Ebola vaccination campaign on the evolving landscape of vaccines and pregnancy

Predicting patent challenges for small-molecule drugs: A cross-sectional study

Ally Memedovich, Brian Steele, Taylor Orr, Shanzeh Chaudhry, Mina Tadrous, Aaron S. Kesselheim, Aidan Hollis, Reed F. Beall

PLOS Medicine: published February 12, 2025 | https://doi.org/10.1371/journal.pmed.1004540

Depression and physical multimorbidity: A cohort study of physical health condition accrual in UK Biobank

Kelly J. Fleetwood, Bruce Guthrie, Caroline A. Jackson, Paul A. T. Kelly, Stewart W. Mercer, Daniel R. Morales, John D. Norrie, Daniel J. Smith, Cathie Sudlow, Regina Prigge

PLOS Medicine: published February 13, 2025 | https://doi.org/10.1371/journal.pmed.1004532

Cervical cerclage versus cervical pessary with or without vaginal progesterone for preterm birth prevention in twin pregnancies and a short cervix: A two-by-two factorial randomised clinical trial

Yen T. N. He, Ha N. H. Pham, Tri C. Nguyen, Trung Q. Bui, Nhu T. Vuong, Diem T. N. Nguyen, Thanh V. Le, Wentao Li, Cam H. Le, Tuong M. Ho, Ben W. Mol, Vinh Q. Dang, Lan N. Vuong

PLOS Medicine: published February 21, 2025 | https://doi.org/10.1371/journal.pmed.1004526

A systematic review of machine learning-based prognostic models for acute pancreatitis: Towards improving methods and reporting quality

Brian Critelli, Amier Hassan, Ila Lahooti, Lydia Noh, Jun Sung Park, Kathleen Tong, Ali Lahooti, Nathan Matzko, Jan Niklas Adams, Lukas Liss, Justin Quion, David Restrepo, Melica Nikahd, Stacey Culp, Adam Lacy-Hulbert, Cate Speake, James Buxbaum, Jason Bischof, Cemal Yazici, Anna Evans-Phillips, Sophie Terp, Alexandra Weissman, Darwin Conwell, Philip Hart, Mitchell Ramsey, Somashekar Krishna, Samuel Han, Erica Park, Raj Shah, Venkata Akshintala, John A. Windsor, Nikhil K. Mull, Georgios Papachristou, Leo Anthony Celi, Peter Lee

PLOS Medicine: published February 24, 2025 | https://doi.org/10.1371/journal.pmed.1004432

Understanding the quality of ethnicity data recorded in health-related administrative data sources compared with Census 2021 in England

Cameron Razieh, Bethan Powell, Rosemary Drummond, Isobel L. Ward, Jasper Morgan, Myer Glickman, Chris White, Francesco Zaccardi, Jonathan Hope, Veena Raleigh, Ashley Akbari, Nazrul Islam, Thomas Yates, Lisa Murphy, Bilal A. Mateen, Kamlesh Khunti, Vahe Nafilyan

PLOS Medicine: published February 26, 2025 | https://doi.org/10.1371/journal.pmed.1004507

Polygenic risk scores for pan-cancer risk prediction in the Chinese population: A population-based cohort study based on the China Kadoorie Biobank

Meng Zhu, Xia Zhu, Yuting Han, Zhimin Ma, Chen Ji, Tianpei Wang, Caiwang Yan, Ci Song, Canqing Yu, Dianjianyi Sun, Yue Jiang, Jiaping Chen, Ling Yang, Yiping Chen, Huaidong Du, Robin Walters, Iona Y Millwood, Juncheng Dai, Hongxia Ma, Zhengdong Zhang, Zhengming Chen, Zhibin Hu, Jun Lv, Guangfu Jin, Liming Li, Hongbing Shen, on behalf of the China Kadoorie Biobank Collaborative Group

PLOS Medicine: published February 28, 2025 | https://doi.org/10.1371/journal.pmed.1004534