The future is uncertain because some forthcoming events are unpredictable and also because our ability to foresee the myriad consequences of our own actions is limited. Here we studied how humans select actions under such extrinsic and intrinsic uncertainty, in view of the exponentially expanding number of prospects on a branching multivalued visual stimulus. Gepshtein et al.
Image Credit: Gepshtein et al. and Trisha Williams of Pigeon Hole Productions
Editorial
Ten Simple Rules for a Computational Biologist’s Laboratory Notebook
PLOS Computational Biology: published September 10, 2015 | https://doi.org/10.1371/journal.pcbi.1004385
Perspectives
You Are Not Working for Me; I Am Working with You
PLOS Computational Biology: published September 24, 2015 | https://doi.org/10.1371/journal.pcbi.1004387
How to Grow a Computational Biology Lab
PLOS Computational Biology: published September 24, 2015 | https://doi.org/10.1371/journal.pcbi.1004397
The Problem with Phi: A Critique of Integrated Information Theory
PLOS Computational Biology: published September 17, 2015 | https://doi.org/10.1371/journal.pcbi.1004286
Bioinformatics in Africa: The Rise of Ghana?
PLOS Computational Biology: published September 17, 2015 | https://doi.org/10.1371/journal.pcbi.1004308
Research Articles
Predicting Anticancer Drug Responses Using a Dual-Layer Integrated Cell Line-Drug Network Model
PLOS Computational Biology: published September 29, 2015 | https://doi.org/10.1371/journal.pcbi.1004498
miRTex: A Text Mining System for miRNA-Gene Relation Extraction
PLOS Computational Biology: published September 25, 2015 | https://doi.org/10.1371/journal.pcbi.1004391
Implicit Value Updating Explains Transitive Inference Performance: The Betasort Model
PLOS Computational Biology: published September 25, 2015 | https://doi.org/10.1371/journal.pcbi.1004523
Early Characterization of the Severity and Transmissibility of Pandemic Influenza Using Clinical Episode Data from Multiple Populations
PLOS Computational Biology: published September 24, 2015 | https://doi.org/10.1371/journal.pcbi.1004392
Coupling Protein Side-Chain and Backbone Flexibility Improves the Re-design of Protein-Ligand Specificity
PLOS Computational Biology: published September 23, 2015 | https://doi.org/10.1371/journal.pcbi.1004335
Dynamic Integration of Value Information into a Common Probability Currency as a Theory for Flexible Decision Making
PLOS Computational Biology: published September 22, 2015 | https://doi.org/10.1371/journal.pcbi.1004402
Decoding Structural Properties of a Partially Unfolded Protein Substrate: En Route to Chaperone Binding
PLOS Computational Biology: published September 22, 2015 | https://doi.org/10.1371/journal.pcbi.1004496
Automated Identification of Core Regulatory Genes in Human Gene Regulatory Networks
PLOS Computational Biology: published September 22, 2015 | https://doi.org/10.1371/journal.pcbi.1004504
Systematic Prediction of Scaffold Proteins Reveals New Design Principles in Scaffold-Mediated Signal Transduction
PLOS Computational Biology: published September 22, 2015 | https://doi.org/10.1371/journal.pcbi.1004508
The LUX Score: A Metric for Lipidome Homology
PLOS Computational Biology: published September 22, 2015 | https://doi.org/10.1371/journal.pcbi.1004511
Multiscale Mechanical Model of the Pacinian Corpuscle Shows Depth and Anisotropy Contribute to the Receptor’s Characteristic Response to Indentation
PLOS Computational Biology: published September 21, 2015 | https://doi.org/10.1371/journal.pcbi.1004370
An Evolutionary Approach for Identifying Driver Mutations in Colorectal Cancer
PLOS Computational Biology: published September 17, 2015 | https://doi.org/10.1371/journal.pcbi.1004350
A Method to Constrain Genome-Scale Models with 13C Labeling Data
PLOS Computational Biology: published September 17, 2015 | https://doi.org/10.1371/journal.pcbi.1004363
Model-Based Reasoning in Humans Becomes Automatic with Training
PLOS Computational Biology: published September 17, 2015 | https://doi.org/10.1371/journal.pcbi.1004463
Efficient Optimization of Stimuli for Model-Based Design of Experiments to Resolve Dynamical Uncertainty
PLOS Computational Biology: published September 17, 2015 | https://doi.org/10.1371/journal.pcbi.1004488
Shaping Neuronal Network Activity by Presynaptic Mechanisms
PLOS Computational Biology: published September 15, 2015 | https://doi.org/10.1371/journal.pcbi.1004438
Structural Bridges through Fold Space
PLOS Computational Biology: published September 15, 2015 | https://doi.org/10.1371/journal.pcbi.1004466
The Internal Dynamics of Fibrinogen and Its Implications for Coagulation and Adsorption
PLOS Computational Biology: published September 14, 2015 | https://doi.org/10.1371/journal.pcbi.1004346
Dynamical Organization of Syntaxin-1A at the Presynaptic Active Zone
PLOS Computational Biology: published September 14, 2015 | https://doi.org/10.1371/journal.pcbi.1004407
Diversity Waves in Collapse-Driven Population Dynamics
PLOS Computational Biology: published September 14, 2015 | https://doi.org/10.1371/journal.pcbi.1004440
Prospective Optimization with Limited Resources
PLOS Computational Biology: published September 14, 2015 | https://doi.org/10.1371/journal.pcbi.1004501
Steering Evolution with Sequential Therapy to Prevent the Emergence of Bacterial Antibiotic Resistance
PLOS Computational Biology: published September 11, 2015 | https://doi.org/10.1371/journal.pcbi.1004493
Social Feedback and the Emergence of Rank in Animal Society
PLOS Computational Biology: published September 10, 2015 | https://doi.org/10.1371/journal.pcbi.1004411
A Gene Gravity Model for the Evolution of Cancer Genomes: A Study of 3,000 Cancer Genomes across 9 Cancer Types
PLOS Computational Biology: published September 9, 2015 | https://doi.org/10.1371/journal.pcbi.1004497
Increased Aggregation Is More Frequently Associated to Human Disease-Associated Mutations Than to Neutral Polymorphisms
PLOS Computational Biology: published September 4, 2015 | https://doi.org/10.1371/journal.pcbi.1004374
Metabolic Adaptation Processes That Converge to Optimal Biomass Flux Distributions
PLOS Computational Biology: published September 4, 2015 | https://doi.org/10.1371/journal.pcbi.1004434
Evolution of Intra-specific Regulatory Networks in a Multipartite Bacterial Genome
PLOS Computational Biology: published September 4, 2015 | https://doi.org/10.1371/journal.pcbi.1004478
A Dynamic Gene Regulatory Network Model That Recovers the Cyclic Behavior of Arabidopsis thaliana Cell Cycle
PLOS Computational Biology: published September 4, 2015 | https://doi.org/10.1371/journal.pcbi.1004486
A Self-Organising Model of Thermoregulatory Huddling
PLOS Computational Biology: published September 3, 2015 | https://doi.org/10.1371/journal.pcbi.1004283
Relating Alpha Power and Phase to Population Firing and Hemodynamic Activity Using a Thalamo-cortical Neural Mass Model
PLOS Computational Biology: published September 3, 2015 | https://doi.org/10.1371/journal.pcbi.1004352
An Emerging Allee Effect Is Critical for Tumor Initiation and Persistence
PLOS Computational Biology: published September 3, 2015 | https://doi.org/10.1371/journal.pcbi.1004366
Examination of the Effects of Heterogeneous Organization of RyR Clusters, Myofibrils and Mitochondria on Ca2+ Release Patterns in Cardiomyocytes
PLOS Computational Biology: published September 3, 2015 | https://doi.org/10.1371/journal.pcbi.1004417
Self-organization in Balanced State Networks by STDP and Homeostatic Plasticity
PLOS Computational Biology: published September 3, 2015 | https://doi.org/10.1371/journal.pcbi.1004420
ReproPhylo: An Environment for Reproducible Phylogenomics
PLOS Computational Biology: published September 3, 2015 | https://doi.org/10.1371/journal.pcbi.1004447
Explaining the Timing of Natural Scene Understanding with a Computational Model of Perceptual Categorization
PLOS Computational Biology: published September 3, 2015 | https://doi.org/10.1371/journal.pcbi.1004456
An Integrated Framework Advancing Membrane Protein Modeling and Design
PLOS Computational Biology: published September 1, 2015 | https://doi.org/10.1371/journal.pcbi.1004398
A Theory of Cheap Control in Embodied Systems
PLOS Computational Biology: published September 1, 2015 | https://doi.org/10.1371/journal.pcbi.1004427
Analysis of Nearly One Thousand Mammalian Mirtrons Reveals Novel Features of Dicer Substrates
PLOS Computational Biology: published September 1, 2015 | https://doi.org/10.1371/journal.pcbi.1004441
Mapping the Conformation Space of Wildtype and Mutant H-Ras with a Memetic, Cellular, and Multiscale Evolutionary Algorithm
PLOS Computational Biology: published September 1, 2015 | https://doi.org/10.1371/journal.pcbi.1004470
Scalability of Asynchronous Networks Is Limited by One-to-One Mapping between Effective Connectivity and Correlations
PLOS Computational Biology: published September 1, 2015 | https://doi.org/10.1371/journal.pcbi.1004490