Activation of Parkin by PINK1-dependent phosphorylation of Serine-65 initiates a cleft widening between the UBL domain and the adjacent linker region that propagates through release of the E2 binding region and further conformational adjustments of the active site region. The UBL domain begins its dynamic movement on the left side. Phospho-Ser65 is indicated by the 'black hole' in the UBL domain positioned on top right near the active site after its movement. See Caulfield et al.
Image Credit: Thomas R. Caulfield
Editorial
Ten Simple Rules to Achieve Conference Speaker Gender Balance
PLOS Computational Biology: published November 20, 2014 | https://doi.org/10.1371/journal.pcbi.1003903
Education Articles
Computational Thinking in Life Science Education
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Teaching Bioinformatics in Concert
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Deep Supervised, but Not Unsupervised, Models May Explain IT Cortical Representation
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