Many experiments suggest that the sustainability of an ecosystem depends on its spatial structure; when a local subpopulation goes extinct the empty habitat patch is "rescued" by immigrants from nearby patches. Trying to protect endangered species via the construction of conservation corridors, the engineer faces a Goldilocks problem: weak migration does not allow for the rescue of empty patches; strong migration leads to spatial coherence and global extinction. In this work, the authors show that maximum sustainability is achieved when the migration rate is tuned to the value that yields a checkerboard spatial pattern (see Ben Zion et al., doi:10.1371/journal.pcbi.1000643).
Image Credit: Gur Yaari (Yale University)
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Getting Started in Structural Phylogenomics
PLOS Computational Biology: published January 29, 2010 | https://doi.org/10.1371/journal.pcbi.1000621
Live Coverage of Intelligent Systems for Molecular Biology/European Conference on Computational Biology (ISMB/ECCB) 2009
PLOS Computational Biology: published January 29, 2010 | https://doi.org/10.1371/journal.pcbi.1000640
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Live Coverage of Scientific Conferences Using Web Technologies
PLOS Computational Biology: published January 29, 2010 | https://doi.org/10.1371/journal.pcbi.1000563
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Functional Characterization of Transcription Factor Motifs Using Cross-species Comparison across Large Evolutionary Distances
PLOS Computational Biology: published January 29, 2010 | https://doi.org/10.1371/journal.pcbi.1000652
Axonal Velocity Distributions in Neural Field Equations
PLOS Computational Biology: published January 29, 2010 | https://doi.org/10.1371/journal.pcbi.1000653
Identification of Crosstalk between Phosphoprotein Signaling Pathways in RAW 264.7 Macrophage Cells
PLOS Computational Biology: published January 29, 2010 | https://doi.org/10.1371/journal.pcbi.1000654
FluTE, a Publicly Available Stochastic Influenza Epidemic Simulation Model
PLOS Computational Biology: published January 29, 2010 | https://doi.org/10.1371/journal.pcbi.1000656
A Reaction-Diffusion Model of ROS-Induced ROS Release in a Mitochondrial Network
PLOS Computational Biology: published January 29, 2010 | https://doi.org/10.1371/journal.pcbi.1000657
Acute Effects of Sex Steroid Hormones on Susceptibility to Cardiac Arrhythmias: A Simulation Study
PLOS Computational Biology: published January 29, 2010 | https://doi.org/10.1371/journal.pcbi.1000658
Protein Interaction Networks—More Than Mere Modules
PLOS Computational Biology: published January 29, 2010 | https://doi.org/10.1371/journal.pcbi.1000659
Recombination Rate and Selection Strength in HIV Intra-patient Evolution
PLOS Computational Biology: published January 29, 2010 | https://doi.org/10.1371/journal.pcbi.1000660
Automatic Assignment of EC Numbers
PLOS Computational Biology: published January 29, 2010 | https://doi.org/10.1371/journal.pcbi.1000661
Optimizing Metapopulation Sustainability through a Checkerboard Strategy
PLOS Computational Biology: published January 22, 2010 | https://doi.org/10.1371/journal.pcbi.1000643
SnugDock: Paratope Structural Optimization during Antibody-Antigen Docking Compensates for Errors in Antibody Homology Models
PLOS Computational Biology: published January 22, 2010 | https://doi.org/10.1371/journal.pcbi.1000644
Hydrogen-Bond Driven Loop-Closure Kinetics in Unfolded Polypeptide Chains
PLOS Computational Biology: published January 22, 2010 | https://doi.org/10.1371/journal.pcbi.1000645
A Neurophysiologically Plausible Population Code Model for Feature Integration Explains Visual Crowding
PLOS Computational Biology: published January 22, 2010 | https://doi.org/10.1371/journal.pcbi.1000646
Quantitative Modeling of GRK-Mediated β2AR Regulation
PLOS Computational Biology: published January 22, 2010 | https://doi.org/10.1371/journal.pcbi.1000647
A Multidimensional Strategy to Detect Polypharmacological Targets in the Absence of Structural and Sequence Homology
PLOS Computational Biology: published January 22, 2010 | https://doi.org/10.1371/journal.pcbi.1000648
Blurring of High-Resolution Data Shows that the Effect of Intrinsic Nucleosome Occupancy on Transcription Factor Binding is Mostly Regional, Not Local
PLOS Computational Biology: published January 22, 2010 | https://doi.org/10.1371/journal.pcbi.1000649
How Synchronization Protects from Noise
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Knots: Attractive Places with High Path Tortuosity in Mouse Open Field Exploration
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An Integrative -omics Approach to Identify Functional Sub-Networks in Human Colorectal Cancer
PLOS Computational Biology: published January 15, 2010 | https://doi.org/10.1371/journal.pcbi.1000639
Associating Genes and Protein Complexes with Disease via Network Propagation
PLOS Computational Biology: published January 15, 2010 | https://doi.org/10.1371/journal.pcbi.1000641
A Bayesian Partition Method for Detecting Pleiotropic and Epistatic eQTL Modules
PLOS Computational Biology: published January 15, 2010 | https://doi.org/10.1371/journal.pcbi.1000642
Conformational Transitions upon Ligand Binding: Holo-Structure Prediction from Apo Conformations
PLOS Computational Biology: published January 8, 2010 | https://doi.org/10.1371/journal.pcbi.1000634
Network-Free Inference of Knockout Effects in Yeast
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Combining Structure and Sequence Information Allows Automated Prediction of Substrate Specificities within Enzyme Families
PLOS Computational Biology: published January 8, 2010 | https://doi.org/10.1371/journal.pcbi.1000636
Identification of Networks of Co-Occurring, Tumor-Related DNA Copy Number Changes Using a Genome-Wide Scoring Approach
PLOS Computational Biology: published January 1, 2010 | https://doi.org/10.1371/journal.pcbi.1000631
Modeling Mitochondrial Bioenergetics with Integrated Volume Dynamics
PLOS Computational Biology: published January 1, 2010 | https://doi.org/10.1371/journal.pcbi.1000632
Disentangling Direct from Indirect Co-Evolution of Residues in Protein Alignments
PLOS Computational Biology: published January 1, 2010 | https://doi.org/10.1371/journal.pcbi.1000633