Linear models of volumetric changes in healthy aging (right diagonal) and Alzheimer's disease (left diagonal). The healthy aging model shows voxel-wise changes in grey matter volume from age 50 to 80 y, with the 50-y-old brain as baseline. The Alzheimer's disease model shows voxel-wise grey matter volume changes with increased symptom severity as measured by the Mini Mental State Examination score (range 30 to 20) and controlled for changes observed in healthy aging. The 3D plot at the bottom left displays both models for a single voxel. See Dukart et al.
Image Credit: Juergen Dukart
Education Articles
Chapter 15: Disease Gene Prioritization
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Chapter 16: Text Mining for Translational Bioinformatics
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Chapter 17: Bioimage Informatics for Systems Pharmacology
PLOS Computational Biology: published April 25, 2013 | https://doi.org/10.1371/journal.pcbi.1003043
Perspective
A Healthy Fear of the Unknown: Perspectives on the Interpretation of Parameter Fits from Computational Models in Neuroscience
PLOS Computational Biology: published April 4, 2013 | https://doi.org/10.1371/journal.pcbi.1003015
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PLOS Computational Biology: published April 25, 2013 | https://doi.org/10.1371/journal.pcbi.1003030
Bayesian Computation Emerges in Generic Cortical Microcircuits through Spike-Timing-Dependent Plasticity
PLOS Computational Biology: published April 25, 2013 | https://doi.org/10.1371/journal.pcbi.1003037
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