Figures
Conducting pathway in a monolayer of cardiac tissue
This image is an immunocytochemical confocal tile scan of cardiac cell culture with a high fraction of non-conducting cells (69%), where conducting cardiac cells are labelled with anti-α-actinin antibody and coloured in pink. Kudryashova et al. show in this issue that cardiac cells can form a conductive pathway (pink cells outlined in white), which enables electrical wave propagation despite a paradoxically small number of conducting cells. Such self-organisation into a connected branching network can be explained by alignment of cytoskeletons in the neighbouring cells, as demonstrated in a computer model.
Image Credit: Aygul Nizamieva
Citation: (2019) PLoS Computational Biology Issue Image | Vol. 15(3) March 2019. PLoS Comput Biol 15(3): ev15.i03. https://doi.org/10.1371/image.pcbi.v15.i03
Published: March 31, 2019
Copyright: © 2019 Nizamieva. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
This image is an immunocytochemical confocal tile scan of cardiac cell culture with a high fraction of non-conducting cells (69%), where conducting cardiac cells are labelled with anti-α-actinin antibody and coloured in pink. Kudryashova et al. show in this issue that cardiac cells can form a conductive pathway (pink cells outlined in white), which enables electrical wave propagation despite a paradoxically small number of conducting cells. Such self-organisation into a connected branching network can be explained by alignment of cytoskeletons in the neighbouring cells, as demonstrated in a computer model.
Image Credit: Aygul Nizamieva