About the Authors

David W. Eyre

david.eyre@ndm.ox.ac.uk

Affiliations Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, United Kingdom

Madeleine L. Cule

Affiliations NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, United Kingdom, Department of Statistics, University of Oxford, Oxford, United Kingdom

David Griffiths

Affiliations Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Department of Statistics, University of Oxford, Oxford, United Kingdom

Derrick W. Crook

Affiliations Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Department of Statistics, University of Oxford, Oxford, United Kingdom

Tim E. A. Peto

Affiliations Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Department of Statistics, University of Oxford, Oxford, United Kingdom

A. Sarah Walker

Contributed equally to this work with: A. Sarah Walker, Daniel J. Wilson

Affiliations Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Department of Statistics, University of Oxford, Oxford, United Kingdom, Medical Research Council, Clinical Trials Unit, London, United Kingdom

Daniel J. Wilson

Contributed equally to this work with: A. Sarah Walker, Daniel J. Wilson

Affiliations Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Wellcome Trust Centre for Human Genetics, Oxford, United Kingdom

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DWE MLC DWC TEAP ASW DJW. Performed the experiments: DWE DG DJW. Analyzed the data: DWE ASW DJW. Wrote the paper: DWE MLC DG DWC TEAP ASW DJW.