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Current Issue May 2023

05/04/2023

Research Article

An integrated model for predicting KRAS dependency

The clinical approvals of KRAS G12C inhibitors have been a revolutionary advance in precision oncology, but response rates are often modest. By integrating molecular profiles of a large panel of cell lines from the DEMETER2 dataset, this study built a binary classifier to predict a tumor’s KRAS dependency.

Image credit: NIH

An integrated model for predicting KRAS dependency

05/01/2023

Research Article

Data-driven segmentation of cortical calcium dynamics

Researchers have been able to record from a large population of neurons across the cortex using calcium indicators in awake, behaving mice; however, many confounding neuronal signals (ie. neurons from different depths) or tissue dynamics (ie. blood flow) influence these recordings. This study identified distinct signals and spatially segment the signal sources into components that can be characterized.

Data-driven segmentation of cortical calcium dynamics

Image credit:

04/04/2023

Research Article

Neural spiking for causal inference and learning

Despite significant research, models of spiking neural networks still lag behind artificial neural networks in terms of performance in machine learning and modeling cognitive tasks. Given this, we may wonder, why do neurons spike? A key problem that must be solved in any neural network is the credit assignment problem

Neural spiking for causal inference and learning

Image credit: Lansdell & Kording

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PLOS Computational Biology | ISSN: 1553-7358 (online)