September 9, 2022
Image credit: Johnson, Bianco and Finley
09/07/2022
Research Article
Orädd and colleagues used computer simulations of full-length ATP7B to study how structural dynamics in the regulatory tail differ between copper-bound and copper-free states.
Image credit: Orädd et al, pcbi.1010074
Current Issue September 2022
09/08/2022
Research Article
In this new study, Gibbs et al develop a new model to approach a longstanding challenge in community ecology; trying to understand how diverse ecosystems assemble and stably persist.
Image credit: Gibbs et al, pcbi.1010521
09/08/2022
Research Article
Lau et al compare one of the most widely used semi-mechanistic models for measles (TSIR) with a commonly used machine learning approach (LASSO), comparing performance and limits in predicting short to long term outbreaks of measles.
Image credit: Lau et al, pcbi.1010251
09/08/2022
Research Article
In this Benchmarking study, Cappellato, Baruzzo and Di Camillo investigated differential abundance methods in microbiome data.
Image credit: Cappellato, Baruzzo and Di Camillo, pcbi.1010467
09/12/2022
Research Article
In this new study, Yang and Henao developed a deep learning method to predict transcription factor binding sites based on chromatin accessibility profiles.
Image credit: Yang and Henao, pcbi.1009921
09/13/2022
Research Article
Allen et al introduce a novel computational model of interoceptive inference in which a synthetic agent’s perceptual beliefs are coupled to the rhythm of the heart.
Image credit: Allen et al, pcbi.1010490
11/11/2021
Featured Issue Image
Gorman et al investigated how neural connectivity and single-neuron computation may contribute to the emergence of spatial selectivity in auditory neurons in the barn owl's midbrain.
Image credit: José Luis Peña
08/02/2021
FEATURED COLLECTION
The reproducibility of research is a crucial element to keep science moving forward.
Image credit: PLOS
06/02/2022
Editorial (invitation only)
A report on the impact of the enhanced code sharing policy at PLOS Computational Biology, one year on from launch.
Image credit: Pexels, Pixabay
This Collection aims to increase the coverage of computational biology-related topics in Wikipedia by rewarding authors with a citable, PubMed-indexed static version of the living document on Wikipedia.
This series of perspective articles from computational biologists in a variety of countries, offers their personal viewpoint on the history, current status, and future of computational biology in their region.
This collection aims to provide practical tutorials and background information on important computational methods used to investigate key biological questions, as well as resources for training scientists at all stages of their careers.
The Benchmarking collection help readers decide between a number of methods which are developed to solve scientific problems.
Knowledge-guided analysis of "omics" data using the KnowEnG cloud platform
Test accuracy of polymerase chain reaction methods against conventional diagnostic techniques for Cutaneous Leishmaniasis (CL) in patients with clinical or epidemiological suspicion of CL: Systematic review and meta-analysis
Murine and related chapparvoviruses are nephro-tropic and produce novel accessory proteins in infected kidneys
Prevalence and genetic profiles of isoniazid resistance in tuberculosis patients: A multicountry analysis of cross-sectional data
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