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Ten simple rules for empowering women in STEM

November 17, 2022

Ten simple rules for empowering women in STEM

This Ten Simple Rules piece provides advice on potential pitfalls and strategies to develop strong female researchers who are correctly credited and recognized for their work.

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02/03/2023

Research Article

LSD-induced increase of Ising temperature and algorithmic complexity of brain dynamics

This study characterizes psychedelics-induced and placebo brain states, as captured in fMRI data, with features derived from the Ising model formalism (system temperature, critical point, susceptibility) and from algorithmic complexity. Under the hypothesis that psychedelics drive the brain into a more disordered state, this study investigates criticality features of brain dynamics under LSD in a within-subject study. 

Image credit: Ruffini et al

LSD-induced increase of Ising temperature and algorithmic complexity of brain dynamics

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Current Issue February 2023

02/02/2023

Research Article

Using ‘sentinel’ plants to improve early detection of invasive plant pathogens

While the presymptomatic period can be long, plant diseases often affect multiple host species, with different epidemiological characteristics. This provides an opportunity for planting sentinel plants, which are alternative host species that display visible symptoms of infection quickly, as early warning beacons for infection. This study uses mathematical modelling to explore the potential for sentinel plants to aid plant disease monitoring programmes

Image credit: Tim Krisztian (Unsplash)

Using ‘sentinel’ plants to improve early detection of invasive plant pathogens

01/20/2023

Research Article

Geometric analysis enables biological insight from complex non-identifiable models using simple surrogates

This study examines the interrelationship between the non-identifiable parameters in a complex model and the identifiable parameters in a simple surrogate mode, aiming to resolve the mismatch between model and data complexity by utilising the simple surrogate model to provide insight where the parameters of interest cannot be determined from the available data.

Image credit: Nick Fewings (Unsplash)

Geometric analysis enables biological insight from complex non-identifiable models using simple surrogates

01/30/2023

Research Article

Bayesian reconstruction of memories stored in neural networks from their connectivity

Theoretical models show how large numbers of memories can be stored in recurrent neural circuits thanks to synaptic plasticity mechanisms. This study asks to what extent it is possible to reconstruct memories stored in a neural circuit from the knowledge of its synaptic connectivity. 

Bayesian reconstruction of memories stored in neural networks from their connectivity

Image credit: Solen Feyissa (Unsplash)

01/30/2023

Research Article

Environmental uncertainty and the advantage of impulsive choice strategies

Impulsive choice behavior, or valuing immediate smaller rewards over larger, delayed rewards, is typically considered to be detrimental in decision-making. This study used Markov Decision Processes to demonstrate that impulsive choices can be beneficial in three common decision-making tasks: Temporal Discounting, Information Sampling and an Explore-Exploit task.

Environmental uncertainty and the advantage of impulsive choice strategies

Image credit: Burk et al

12/30/2022

Research Article

Fine-grained, nonlinear registration of live cell movies reveals spatiotemporal organization of diffuse molecular processes

This study describes a method time-series analysis of local subcellular processes across the entire cell by adapting optical flow based, nonlinear image registration. New capacity of sampling was leveraged at every subcellular location for the discovery of organized Profilin dynamics in symmetry-breaking and polarizing cells.

Fine-grained, nonlinear registration of live cell movies reveals spatiotemporal organization of diffuse molecular processes

Image credit: Jiang et al

11/11/2021

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Diverse brain processing of sound localization in barn owls

Gorman et al investigated how neural connectivity and single-neuron computation may contribute to the emergence of spatial selectivity in auditory neurons in the barn owl's midbrain.

Diverse brain processing of sound localization in barn owls

Image credit: José Luis Peña

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PLOS Computational Biology | ISSN: 1553-7358 (online)