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Trackplot: A flexible toolkit for combinatorial analysis of genomic data

September 5, 2023

Trackplot: A flexible toolkit for combinatorial analysis of genomic data

The authors present Trackplot, a comprehensive tool that delivers high-quality plots via a programmable and interactive web-based platform. Trackplot seamlessly integrates diverse data sources and utilizes a multi-threaded process, enabling users to explore genomic signal in large-scale sequencing datasets.


Image credit: NCI

10/17/2023

Research Article

Integrated information theory (IIT) 4.0: Formulating the properties of phenomenal existence in physical terms

This paper presents Integrated Information Theory (IIT) 4.0. IIT aims to account for the properties of experience in physical (operational) terms. It identifies the essential properties of experience (axioms), infers the necessary and sufficient properties that its substrate must satisfy (postulates), and expresses them in mathematical terms. 

Image credit: Albantakis et al

Integrated information theory (IIT) 4.0: Formulating the properties of phenomenal existence in physical terms

Recently Published Articles

Current Issue

Current Issue November 2023

10/06/2023

Research Article

Force-dependent focal adhesion assembly and disassembly: A computational study

This study presents a differential equation-based mechano-chemical computational model, to investigate how substrate stiffness influences adhesion formation, maturation and disassembly. It explicitly includes the role of talin and vinculin-based reinforcement in these processes. 

Image credit: Shankar et al

Force-dependent focal adhesion assembly and disassembly: A computational study

09/18/2023

Research Article

Nowcasting the 2022 mpox outbreak in England

The 2022 mpox outbreak was characterized by long delays from individuals developing symptoms and reporting a positive case, creating an underestimate of the true extent of the outbreak. The authors developed a mathematical model that accounts for these reporting delays to estimate the true shape of the epidemic curve in real-time. This model was used continuously throughout the outbreak response to provide insight to the incident management team at the UK Health Security Agency.

Nowcasting the 2022 mpox outbreak in England

Image credit: Midas Hofstra

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PLOS Computational Biology | ISSN: 1553-7358 (online)