April 27, 2023
Image credit: PLOS pcbi.1010627
04/26/2023
Research Article
Rhodotorula toruloides is a nonpathogenic, nonconventional yeast that has recently emerged as one of the most promising yeasts for sustainable production of chemicals and fuels due to its natural ability to synthesize large amounts of lipids. However, its unique metabolic properties are not yet fully understood.
Current Issue April 2023
05/05/2023
Research Article
The perceived duration of an event is biased by the mean duration of events observed in a relatively long period and also by the durations of recently processed events. This study asked whether these two effects reflect the operation of separate mechanisms or a unitary mechanism.
Image credit: Nathan Dumlao (Unsplash)
05/04/2023
Research Article
The clinical approvals of KRAS G12C inhibitors have been a revolutionary advance in precision oncology, but response rates are often modest. By integrating molecular profiles of a large panel of cell lines from the DEMETER2 dataset, this study built a binary classifier to predict a tumor’s KRAS dependency.
Image credit: NIH
05/01/2023
Research Article
Researchers have been able to record from a large population of neurons across the cortex using calcium indicators in awake, behaving mice; however, many confounding neuronal signals (ie. neurons from different depths) or tissue dynamics (ie. blood flow) influence these recordings. This study identified distinct signals and spatially segment the signal sources into components that can be characterized.
Image credit:
04/28/2023
Research Article
Do current artificial visual systems known as deep convolutional neural networks (DCNNs) represent the world as humans do? This study reveals DCNNs are able to capture important representational aspects of human vision both at the behavioral and neural levels.
04/04/2023
Research Article
Despite significant research, models of spiking neural networks still lag behind artificial neural networks in terms of performance in machine learning and modeling cognitive tasks. Given this, we may wonder, why do neurons spike? A key problem that must be solved in any neural network is the credit assignment problem
Image credit: Lansdell & Kording
04/04/2023
Research Article
Software for genome visualization still lacks automation, integration of different analyses, and customizable options for non-experienced users
Image credit: Cumsille et al
04/03/2023
Research Article
Motor learning involves a widespread brain network, however little is known about how this network learns motor tasks and which role different parts of this network take.
Image credit: Milad Fekurian
06/02/2022
Editorial (invitation only)
A report on the impact of the enhanced code sharing policy at PLOS Computational Biology, one year on from launch.
Image credit: Pexels, Pixabay
This Collection aims to increase the coverage of computational biology-related topics in Wikipedia by rewarding authors with a citable, PubMed-indexed static version of the living document on Wikipedia.
This series of perspective articles from computational biologists in a variety of countries, offers their personal viewpoint on the history, current status, and future of computational biology in their region.
This collection aims to provide practical tutorials and background information on important computational methods used to investigate key biological questions, as well as resources for training scientists at all stages of their careers.
The Benchmarking collection help readers decide between a number of methods which are developed to solve scientific problems.
Knowledge-guided analysis of "omics" data using the KnowEnG cloud platform
Test accuracy of polymerase chain reaction methods against conventional diagnostic techniques for Cutaneous Leishmaniasis (CL) in patients with clinical or epidemiological suspicion of CL: Systematic review and meta-analysis
Murine and related chapparvoviruses are nephro-tropic and produce novel accessory proteins in infected kidneys
Prevalence and genetic profiles of isoniazid resistance in tuberculosis patients: A multicountry analysis of cross-sectional data
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