November 9, 2022
Image credit: Matthews and Schuster et al pcbi.1010584
11/08/2022
Research Article
In this study, Gu et al show how a burst of local translation in synapses can be silenced following a stimulation pulse, and explores the CPEB3/SUMO2 interplay underlying the structural change of synapses and the formation of long-term memories.
Image credit: Gu et al, pcbi.1010657
Current Issue October 2022
11/07/2022
Research Article
The ability to create computer simulations of epidemics is important to be able to predict where and when people will be become infected, identify factors which either contribute to or slow disease spread, and test various interventions without risking real lives. These researchers study methods for fitting parameters, such as infectiousness, to real world data so that the disease simulator correctly represents the actual disease.
Image credit: Smedemark-Margulies and Walters et al, pcbi.1010591
11/14/2022
Research Article
In this new study, Desmet, Cusumano and Dingwell establish a theoretical basis for how humans make lateral maneuvers while walking, and their results demonstrate that humans might use evolving cost landscapes in real time to perform such an adaptive motor task and, furthermore, that such adaptation can occur quickly–over only one step.
Image credit: Desmet, Cusumano and Dingwell, pcbi.1010035
11/02/2022
Research Article
In this new study, Sanz Perl et al explored the question of how and why do complex, fluctuating, and oscillating dynamics characterise brain states? They showed that the fluctuations regime provides maximal flexibility to the human brain, a desirable property for brain dynamics to interact with the environment.
Image credit: Sanz Perl et al, pcbi.1010662
11/03/2022
Research Article
Using a model network of leaky integrate-and-fire neurons with spike-timing-dependent plasticity and theoretical analysis, Kromer and Tass show how the relative timings between and the shape of delivered stimuli can be tuned to down-regulate certain synaptic connections while up-regulating others.
Image credit: Kromer and Tass, pcbi.1010568
11/15/2022
Research Article
In this new paper, Nieto-Castanon discusses fc-MVPA (functional connectivity Multivariate Pattern Analysis), a novel method using multivariate pattern analysis techniques in the context of brain-wide connectome inferences.
Image credit: Nieto-Castanon, pcbi.1010634
11/11/2021
Featured Issue Image
Gorman et al investigated how neural connectivity and single-neuron computation may contribute to the emergence of spatial selectivity in auditory neurons in the barn owl's midbrain.
Image credit: José Luis Peña
08/02/2021
FEATURED COLLECTION
The reproducibility of research is a crucial element to keep science moving forward.
Image credit: PLOS
06/02/2022
Editorial (invitation only)
A report on the impact of the enhanced code sharing policy at PLOS Computational Biology, one year on from launch.
Image credit: Pexels, Pixabay
This Collection aims to increase the coverage of computational biology-related topics in Wikipedia by rewarding authors with a citable, PubMed-indexed static version of the living document on Wikipedia.
This series of perspective articles from computational biologists in a variety of countries, offers their personal viewpoint on the history, current status, and future of computational biology in their region.
This collection aims to provide practical tutorials and background information on important computational methods used to investigate key biological questions, as well as resources for training scientists at all stages of their careers.
The Benchmarking collection help readers decide between a number of methods which are developed to solve scientific problems.
Knowledge-guided analysis of "omics" data using the KnowEnG cloud platform
Test accuracy of polymerase chain reaction methods against conventional diagnostic techniques for Cutaneous Leishmaniasis (CL) in patients with clinical or epidemiological suspicion of CL: Systematic review and meta-analysis
Murine and related chapparvoviruses are nephro-tropic and produce novel accessory proteins in infected kidneys
Prevalence and genetic profiles of isoniazid resistance in tuberculosis patients: A multicountry analysis of cross-sectional data
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