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February 27, 2025

PLOS statement on recent US Executive Orders

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01/29/2025

Research Article

The role of oscillations in grid cells’ toroidal topology

The authors present a quantitative approach to evaluating the role of various aspects of data in the emergence of low dimensional, topological, features. Topological features are those that are insensitive to certain deformations of an object, e.g. stretching, but not cutting.

The role of oscillations in grid cells’ toroidal topology

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Current Issue February 2025

01/23/2025

Education

The tumour histopathology “glossary” for AI developers

However, effective translation of AI and deep learning methods requires computational researchers to have at least a basic understanding of histopathology. This work aims to bridge that gap by introducing essential histopathology concepts to support AI developers in their research.

Image credit: Mandal et al

The tumour histopathology “glossary” for AI developers

01/10/2025

Education

Ten simple rules for good model-sharing practices

This paper suggests 10 simple rules for you to both (i) ensure you share models in a way that is at least “good enough,” and (ii) enable others to lead the change towards better model-sharing practices.

Ten simple rules for good model-sharing practices

Image credit: Fabio (Unsplash)

01/07/2025

Research Article

Benchmarking uncertainty quantification for protein engineering

In many cases, the goal of conducting new experiments in protein design is optimizing for a property or improving the machine learning model. Many standard methods for these two tasks require good estimates of the uncertainty in the model’s predictions.

Benchmarking uncertainty quantification for protein engineering

Image credit: NCI

12/26/2024

Research Article

Properties of winning Iterated Prisoner’s Dilemma strategies

This study analyzed the performance of a large and diverse collection of IPD strategies across thousands of computer tournaments. While no single strategy consistently excels, successful strategies share key characteristics.

Properties of winning Iterated Prisoner’s Dilemma strategies

Image credit: GR Stocks

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PLOS Computational Biology | ISSN: 1553-7358 (online)